Cysteine Leukotriene Receptor Antagonist-Montelukast Effects on Diabetic Retinal Microvascular Endothelial Cells Curtail Autophagy
Dysfunctional retinal endothelium initiates a self-reinforcing loop of inflammation, autophagy, and compromised integrity associated with heightened CysLTR1 levels. The antagonistic effect of montelukast against CysLTR1 effectively mitigates these detrimental changes. This study reveals CysLTR1 as a potential therapeutic target in treating DME and offers a novel strategy to mitigate detrimental changes in DR.
Authors
- Rajashekhar Gangaraju (ORCID: https://orcid.org/0000-0002-6664-8286)
- Rania R. Abdеlaziz
- Sally L. Elshaer
- Amritha T. M. Seetharaman
- Ahmed Awad (ORCID: https://orcid.org/0000-0001-5904-7143)
- Mohammad Shahadat Hossain (ORCID: https://orcid.org/0000-0002-8762-8989)
- Manar A. Nader (ORCID: https://orcid.org/0000-0002-8590-2622)
Institutions
- Mansoura University (EG)
- University of Tennessee Health Science Center (US)
Publication Details
- Journal
- Investigative Ophthalmology & Visual Science
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1167/iovs.65.13.15
- Citations
- 7
- Primary Topic
- Retinal Diseases and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 3.77
Funders
- U.S. Department of Defense
- Research to Prevent Blindness
- Egyptian Cultural and Educational Bureau
- Mansoura University