Beneficial Impact of Vaccination Against SARS-CoV-2 on the Mental Health of IPF Patients
<b>Background</b>: Depression and anxiety represent significant comorbidities in idiopathic pulmonary fibrosis (IPF) patients, affecting their quality of life. The COVID-19 pandemic has had an uneven impact on global mental health. The Hospital Anxiety and Depression Scale (HADS) constitutes a validated tool to identify anxiety disorders and depression. The aim of this multicentre study was to evaluate the effect of COVID-19 vaccination on depression and anxiety in IPF patients. <b>Methods</b>: Consecutive IPF patients (median 73.5 years) who are regularly followed-up with were included in the study. Demographics, functional, and clinical were recorded. The HADS score was calculated before and one month after vaccination against COVID-19 in all participants. A Wilcoxon signed ranks test was conducted. <b>Results</b>: A total of 180 IPF patients (median 73.5 years) were included in the study. Among them, 145 patients (81%) received antifibrotic treatment. A significant reduction in HADS, both in anxiety and depression scales, was observed one month after vaccination against SARS-COV-2), independent of age, smoking, lung function impairment, and prior history of depression (<i>p</i> < 0.01). <b>Conclusions</b>: A higher Hospital Anxiety and Depression Scale score was detected before vaccination against COVID-19. It seems that vaccination also offered a beneficial effect on depression and anxiety in IPF patients, independent of age, smoking, lung function impairment, and prior history of depression.
Authors
- Paschalis Ntolios (ORCID: https://orcid.org/0000-0002-7875-3905)
- Andriana Ι. Papaioannou (ORCID: https://orcid.org/0000-0001-9708-3241)
- Anna Karakatsani (ORCID: https://orcid.org/0000-0002-3275-2026)
- Argyrios Tzouvelekis (ORCID: https://orcid.org/0000-0002-6295-1384)
- Athena Gogali (ORCID: https://orcid.org/0000-0002-4321-9446)
- Konstantinos Tatsis (ORCID: https://orcid.org/0000-0002-5984-3649)
- P Tsiri
- Vasilios Tzilas (ORCID: https://orcid.org/0000-0002-7030-6166)
- Lykourgos Kolilekas (ORCID: https://orcid.org/0000-0002-4420-609X)
- Vasiliki Apollonatou (ORCID: https://orcid.org/0000-0002-9060-294X)
- Demosthenes Bouros (ORCID: https://orcid.org/0000-0002-0685-0765)
- Zoe Daniil (ORCID: https://orcid.org/0000-0002-1058-9125)
- Elvira-Markella Antonogiannaki
- Aggeliki Haritou
- Paraskevi Kirgou
- Paschalis Steiropoulos (ORCID: https://orcid.org/0000-0001-7121-6253)
- Stelios Loukides (ORCID: https://orcid.org/0000-0002-4278-9922)
- Ilias Dimeas (ORCID: https://orcid.org/0000-0001-6933-1068)
- Katerina M. Antoniou (ORCID: https://orcid.org/0009-0006-0207-4582)
- Emmanouil K. Symvoulakis (ORCID: https://orcid.org/0000-0002-5650-5513)
- Effrosyni D. Manali (ORCID: https://orcid.org/0000-0002-1731-7069)
- Katherine Samaras (ORCID: https://orcid.org/0000-0003-3007-7335)
- Areti Xyfteri
- Ioannis P. Tomos (ORCID: https://orcid.org/0000-0002-9978-4823)
- Maria Kallieri (ORCID: https://orcid.org/0000-0002-4282-4249)
- Ιlias Papanikolaou (ORCID: https://orcid.org/0000-0003-1391-2925)
- Spyros Papiris
- Maria Maniati
Institutions
- University of Crete (GR)
- University of Thessaly (GR)
- Democritus University of Thrace (GR)
- University of Patras (GR)
- University of Ioannina (GR)
- National and Kapodistrian University of Athens (GR)
- General University Hospital of Patras (GR)
- Corfu General Clinic (GR)
- Sotiria General Hospital (GR)
Publication Details
- Journal
- Advances in respiratory medicine
- Published
- 2024-11-06
- DOI
- https://doi.org/10.3390/arm92060042
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00