Clinical outcomes of patients diagnosed with <i>SETBP1</i> mutated myeloid neoplasms

SETBP1 mutations (m) have been previously reported in myeloid neoplasms and are associated with poor prognostic co-mutations and cytogenetic abnormalities. We retrospectively analyzed the charts of 113 patients diagnosed with myeloid neoplasms with SETBP1m. The most common diagnosis was MDS (31%). Cytogenetics were abnormal in 51 cases (46.4%), with monosomy 7 being the most common (41.1%). The most frequent co-mutations were ASXL1 (71.7%), SRSF2 (46.9%), TET2 (20.4%). Higher SETBP1m VAF was associated with proliferative features (<i>p</i> < 0.05). Most SETBP1m (96.5%) were in one of three hotspots (Asp868, Gly870, Ile871), with Asp868m being most frequent (51.3%). Patients with Ile871m had higher number of co-mutations (median= 4) compared to Asp868m and Gly870m (<i>p</i> = 0.07). On multivariate analysis, age ≥ 70 years (<i>p</i> = 0.004) and higher peripheral blood blasts (<i>p</i> = 0.02) had worse OS. Patients with Ile871m had lower OS when compared with Asp868m and Gly870m (5.5 months vs. 17.4 and 17 months, respectively, <i>p</i> = 0.1).

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Publication Details

Journal
Leukemia & lymphoma/Leukemia and lymphoma
Published
2024-11-06
DOI
https://doi.org/10.1080/10428194.2024.2425048
Citations
1
Primary Topic
Acute Myeloid Leukemia Research
Type
article
Field-Weighted Citation Impact
0.45
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article

Clinical outcomes of patients diagnosed with SETBP1 mutated myeloid neoplasms

Antoine N. Saliba, Aref Al‐Kali, Abhishek Avinash Mangaonkar, Mithun Vinod Shah et al.
1 citations
Leukemia & lymphoma/Leukemia and lymphoma
Acute Myeloid Leukemia Research
0.45
article

Clinical outcomes of patients diagnosed with SETBP1 mutated myeloid neoplasms

Antoine N. Saliba, Aref Al‐Kali, Abhishek Avinash Mangaonkar, Mithun Vinod Shah, Dragan Jevremović, James M. Foran, Rong He, Anmol Baranwal, Jeanne Palmer, Hassan B. Alkhateeb, Mehrdad Hefazi, Mrinal M. Patnaik, Patricia T. Greipp, Kebede H. Begna, William J. Hogan, Kurt Bessonen, Yazan Jabban, Mahmoud Yacout, David S. Viswanatha
article en
1 citations

Abstract

SETBP1 mutations (m) have been previously reported in myeloid neoplasms and are associated with poor prognostic co-mutations and cytogenetic abnormalities. We retrospectively analyzed the charts of 113 patients diagnosed with myeloid neoplasms with SETBP1m. The most common diagnosis was MDS (31%). Cytogenetics were abnormal in 51 cases (46.4%), with monosomy 7 being the most common (41.1%). The most frequent co-mutations were ASXL1 (71.7%), SRSF2 (46.9%), TET2 (20.4%). Higher SETBP1m VAF was associated with proliferative features (<i>p</i> < 0.05). Most SETBP1m (96.5%) were in one of three hotspots (Asp868, Gly870, Ile871), with Asp868m being most frequent (51.3%). Patients with Ile871m had higher number of co-mutations (median= 4) compared to Asp868m and Gly870m (<i>p</i> = 0.07). On multivariate analysis, age ≥ 70 years (<i>p</i> = 0.004) and higher peripheral blood blasts (<i>p</i> = 0.02) had worse OS. Patients with Ile871m had lower OS when compared with Asp868m and Gly870m (5.5 months vs. 17.4 and 17 months, respectively, <i>p</i> = 0.1).

Leukemia & lymphoma/Leukemia and lymphomaVol. 66(3)
WinnMed (US), Cancer Centers of Southwest Oklahoma (US), Mayo Clinic in Arizona (US), Mayo Clinic in Florida (US)
Openalex Percentile: Top 31%
Acute Myeloid Leukemia Research
0.45
DOISourceOpenAlex
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