Maternal Early Overfeeding Negatively Impacts Cardiac Progenitor Cell Differentiation and Cardiomyocyte Maturation in the Neonatal Offspring
Obese dams negatively impact their offspring, leading to altered biometric and metabolic parameters, along with an immature heart already at birth, with extracellular matrix adverse remodeling, delayed cardiac progenitor cell differentiation, and restrained cardiomyocyte maturation, which can be related to the development of cardiometabolic disease in the adulthood.
Authors
- Thiago Freire (ORCID: https://orcid.org/0000-0002-4089-0920)
- Barbara Bárbara Victoria Almeida e Silva (ORCID: https://orcid.org/0009-0001-4652-5713)
- Andressa Cardoso Guimarães
- Simone Nunes de Carvalho (ORCID: https://orcid.org/0000-0003-3310-2970)
- Erika Cortez (ORCID: https://orcid.org/0000-0003-0262-061X)
- Alessandra Alves Thole (ORCID: https://orcid.org/0000-0001-7909-3497)
- Daniela Caldas de Andrade (ORCID: https://orcid.org/0000-0002-7907-9342)
- Érica Patrícia Garcia‐Souza
- Elaine de Oliveira
Institutions
- Universidade do Estado do Rio de Janeiro (BR)
- Department of Physiological Sciences (RU)
Publication Details
- Journal
- Cells Tissues Organs
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1159/000542436
- Citations
- 2
- Primary Topic
- Birth, Development, and Health
- Type
- article
- Field-Weighted Citation Impact
- 2.22