Comparison of Five Prognostic Scores for Association with Mortality in Malignant Pleural Effusion

Malignant pleural effusion (MPE) is a complication of malignancy, and treatment is based on survival prediction. The aim of our study was to compare the performance characteristics of LENT, PROMISE, RECLS, AL, and NLR scores for survival in lung cancer patients who have MPE. Patients diagnosed with MPE were included in the study and examined retrospectively. All scores were calculated at the time of the diagnosis of MPE. Lung cancer patients who have MPE were admitted to the study, and the 30-day, six-month, and one-year mortality rates were taken as the endpoints. A total of 180 patients were examined; 138 (77%) were male, and the mean age was 65 ± 11 years. At 30 days of mortality, the values of the area under the ROC curve (AUC) (95% CI) were: LENT 0.83 (0.76–0.87), RECLS 0.71 (0.63–0.77), and PROMISE 0.70 (0.17–0.38). At six months and one year, the order of these AUCs was similar. <fig><object-id>erj;64/suppl_68/OA3801/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>The AUCs for the AL and pNLR were not statistically significant at any time. The Cox regression analyses showed that at six months, the LENT score is a better predictor than PROMISE (p = 0.001) and RECLS (p = 0.02). At one year, the LENT score is a better predictor than PROMISE (p = 0.001), and there is no difference between the LENT and RECLS scores (p=0.64). The present study is the first that compares these five scores. We observed that LENT and RECLS scores are prognostic for long-term mortality in lung cancer patients with MPE.