Recurrent respiratory infections and allergy hallmarks at-risk progression to severe asthma

<bold>Background:</bold> Allergic asthma (AA) is associated with an increased risk of infections requiring antibiotics and allergen immunotherapy appears to prevent asthma progression. The association between allergy, recurrent respiratory infections (RRI) and the risk of developing severe asthma (SA) remains unclear. <bold>Aim:</bold> To assess whether RRI and allergy are associated with a higher risk of subsequent development of SA. <bold>Methods:</bold> A group of patients with non-SA with and without allergy was selected from the prospective nationwide population register-based Swedish data from NORdic Dataset for aSThmA Research (NORDSTAR) collaboration platform. Selection criteria was based on the redemption of asthma- and anti-allergic medications. RRI was assessed for a 2-year exposure period and the proportion of patients developing SA was assessed over a 3-year outcome period (Figure 1). <bold>Results:</bold> 401,643 patients fulfilled inclusion criteria (74 215 patients with AA and 327,428 patients with non-AA). RRI were associated with an increased risk of development of SA across both non-AA and AA, but with the highest risk observed in the latter group; OR = 1.51 (1.12, 1.99) and RR = 3.47 (2.49, 4.83) respectively. <bold>Conclusion:</bold> In mild/moderate asthma, RRI are associated with an increased risk of subsequent progression into SA, with the highest risk among moderately-severly allergic individuals, representing hallmarks of patients at-risk developing SA. <fig><object-id>erj;64/suppl_68/OA5571/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Authors

Institutions

Publication Details

Journal
Epidemiology
Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.oa5571
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Recurrent respiratory infections and allergy hallmarks at-risk progression to severe asthma

Asger Sverrild, Arja Viinanen, Birger Norderud Lærum, Emilie Johanning Bari et al.
Epidemiology
Asthma and respiratory diseases
article

Recurrent respiratory infections and allergy hallmarks at-risk progression to severe asthma

Asger Sverrild, Arja Viinanen, Birger Norderud Lærum, Emilie Johanning Bari, Thomas Sandström, Anna von Bülow, Dóra Lúðvíksdóttir, Olivia Ernstsson, Patrik Sandin, Barbro Dahlén, Helena Bäckman, Ole Hilberg, Christer Janson, Tina Skjold, Jussi Karjalainen, Alan Altraja, Sverre Lehmann, Leif Hilding Bjermer, Paula Kauppi, Susanne Hansen, Apostolos Bossios, Charlotte Suppli Ulrik, Unnur Steina Björnsdóttir, Valentyna Yasinska, Kirk Geale, Johannes Martin Schmid, Celeste Porsbjerg, Vibeke Backer, Maritta Kilpeläinen, Hannu Kankarantaa, Bernt Arli, Lauri Lehtmäki
article en

Abstract

<bold>Background:</bold> Allergic asthma (AA) is associated with an increased risk of infections requiring antibiotics and allergen immunotherapy appears to prevent asthma progression. The association between allergy, recurrent respiratory infections (RRI) and the risk of developing severe asthma (SA) remains unclear. <bold>Aim:</bold> To assess whether RRI and allergy are associated with a higher risk of subsequent development of SA. <bold>Methods:</bold> A group of patients with non-SA with and without allergy was selected from the prospective nationwide population register-based Swedish data from NORdic Dataset for aSThmA Research (NORDSTAR) collaboration platform. Selection criteria was based on the redemption of asthma- and anti-allergic medications. RRI was assessed for a 2-year exposure period and the proportion of patients developing SA was assessed over a 3-year outcome period (Figure 1). <bold>Results:</bold> 401,643 patients fulfilled inclusion criteria (74 215 patients with AA and 327,428 patients with non-AA). RRI were associated with an increased risk of development of SA across both non-AA and AA, but with the highest risk observed in the latter group; OR = 1.51 (1.12, 1.99) and RR = 3.47 (2.49, 4.83) respectively. <bold>Conclusion:</bold> In mild/moderate asthma, RRI are associated with an increased risk of subsequent progression into SA, with the highest risk among moderately-severly allergic individuals, representing hallmarks of patients at-risk developing SA. <fig><object-id>erj;64/suppl_68/OA5571/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Epidemiology
Reykjavík University (IS), Karolinska University Hospital (SE), University of Helsinki (FI), Uppsala University Hospital (SE), University of Turku (FI), University of Iceland (IS), Seinäjoki University of Applied Sciences (FI), Helsinki University Hospital (FI), Haukeland University Hospital (NO), Bispebjerg Hospital (DK), Hvidovre Hospital (DK), Turku University Hospital (FI), Tartu University Hospital (EE), Aarhus University Hospital (DK), Rigshospitalet (DK), Karolinska Institutet (SE), Göteborgs Stads (SE), Vejle Sygehus (DK), National University Hospital of Iceland (IS), Tampere University Hospital (FI), Tampere University (FI), Skåne University Hospital (SE), Smerteklinikken (NO), University of Bergen (NO), Umeå University (SE)
Good health and well-being
Openalex Percentile: Top 72%
Asthma and respiratory diseases
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.