Home-based physical activity in ILD: an RCT

Home-based physical activity (PA) in interstitial lung disease (ILD) may be fundamental to tackle physical inactivity. We explored the efficacy and effectiveness of the Lifestyle Integrated Functional Exercise for people with ILD (iLiFE) trial (<ext-link>NCT04224233</ext-link>). An RCT, assessor blinded, was conducted. After the baseline assessment, participants were randomly assigned to the experimental (EG: iLiFE-12-weeks of a home-based PA programme embedded in individuals’ daily routines) or the control (CG: usual care) group. Data were collected before and immediately after iLiFE. Primary outcome was PA (steps/day, time spent in moderate to vigorous PA [MVPA]/day/week). Secondary outcomes were symptoms, muscle strength, functional status, emotional function, healthcare utilisation, exacerbations and falls. Efficacy and effectiveness were assessed using intention-to-treat and per-protocol analysis with linear mixed methods. We included 48 participants (54% female, 67±11yrs, DLCO%p 50±17; nEG/nCG=24/24). Interaction group*time showed that iLiFE was efficacious and effective in maintaining PA levels and in improving muscle strength, functional status and health-related quality of life (p<0.05) in people with ILD (Fig. 1). No other significant interactions were observed. No adverse events were reported. iLiFE is an efficacious and effective intervention to maintain PA levels and improve other health-related domains in people with ILD and may now be considered to improve ILD management. <fig><object-id>erj;64/suppl_68/OA942/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>