Working-life exposome and new-onset COPD: An exposome-wide association study (ExWAS)

<bold>Introduction</bold>: COPD is a leading cause of death worldwide and linked to occupational exposures. We aimed to explore the link between working-life exposome and new-onset COPD, starting with an exposome-wide association study (ExWAS). <bold>Method</bold>: We included two European multi-centre population-based cohorts, ECRHS and Constances. ECRHS began in 1992 (participants 20-44 years) with two follow-ups at ~10 and ~20 years. Constances, baseline 2012-2020 (18-69 years), one follow-up at ~4 years. COPD was defined by FEV1/FVC<Lower limit of normal and at least one respiratory symptom, excluding those with COPD at baseline. Cumulative exposure was assessed at each follow-up for 49 occupational exposures using 5 job exposure matrices. The ExWAS was conducted with discrete-time hazard models adjusted for sex, weight, pack-years of smoking, parental asthma, years between follow-up, physical activity and center. <bold>Results:</bold> Information was available for n=4065, male 51% (ECRHS) and n=5855, male 49% (Constances). In ECRHS we found increased risk of new-onset COPD (adjusted Odds ratios; 95% CI) for exposure to: exhaust fumes (1.12; 1.03-1.21), asbestos (1.13; 1.02-1.24), gas fumes (1.13; 1.1-1.25), biological dust (1.11; 1.0-1.22), heavy lifting (1.13; 1.0-1.25), mineral dust (1.11; 1.0-1.23), and house dust mites (1.07; 1.0-1-15). There was no evidence for effect-modification by asthma status. No clear associations were found for Constances. <bold>Conclusion:</bold> Occupational exposures was linked to increased risk of COPD in ECRHS only, probably due to an older population and longer time of follow-up compared to Constances. This ExWAS set the stage for the next analytical step, assessing the joint effect of the working life-exposme.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.oa974
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1
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Health, Environment, Cognitive Aging
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article
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article

Working-life exposome and new-onset COPD: An exposome-wide association study (ExWAS)

Nicole Le Moual, Wenxin Wan, Cecilie Svanes, Orianne Dumas et al.
1 citations
Health, Environment, Cognitive Aging
0.31
article

Working-life exposome and new-onset COPD: An exposome-wide association study (ExWAS)

Nicole Le Moual, Wenxin Wan, Cecilie Svanes, Orianne Dumas, Anjoeka Pronk, Theodore Lytras, Leopoldo Palacios Gómez, Pascal Demoly, Aziz Sheikh, Lützen Portengen, Marcel Goldberg, Chantal Rahérison, Lídia Casas, Christer Janson, Anne Mette Lund Würtz, Hayat Bentouhami, Jan‐Paul Zock, Lars Modig, Vivi Schlünssen, Caroline Lodge, Rachel Nadif, Geza Benke, Mathias Holm, Judith Garcia, Bénédicte Leynaert, Hans Kromhout, Valérie Siroux, Victoria Alcaraz-Serrano, Henrik Albert Kolstad, T. Gislason, Isabel Urrutia, Debbie Jarvis, Jesús Martínez-Moratalla, Susan Peters, Theresa Moeller Kynde, Jorunn Kierkeleit
article en
1 citations

Abstract

<bold>Introduction</bold>: COPD is a leading cause of death worldwide and linked to occupational exposures. We aimed to explore the link between working-life exposome and new-onset COPD, starting with an exposome-wide association study (ExWAS). <bold>Method</bold>: We included two European multi-centre population-based cohorts, ECRHS and Constances. ECRHS began in 1992 (participants 20-44 years) with two follow-ups at ~10 and ~20 years. Constances, baseline 2012-2020 (18-69 years), one follow-up at ~4 years. COPD was defined by FEV1/FVC<Lower limit of normal and at least one respiratory symptom, excluding those with COPD at baseline. Cumulative exposure was assessed at each follow-up for 49 occupational exposures using 5 job exposure matrices. The ExWAS was conducted with discrete-time hazard models adjusted for sex, weight, pack-years of smoking, parental asthma, years between follow-up, physical activity and center. <bold>Results:</bold> Information was available for n=4065, male 51% (ECRHS) and n=5855, male 49% (Constances). In ECRHS we found increased risk of new-onset COPD (adjusted Odds ratios; 95% CI) for exposure to: exhaust fumes (1.12; 1.03-1.21), asbestos (1.13; 1.02-1.24), gas fumes (1.13; 1.1-1.25), biological dust (1.11; 1.0-1.22), heavy lifting (1.13; 1.0-1.25), mineral dust (1.11; 1.0-1.23), and house dust mites (1.07; 1.0-1-15). There was no evidence for effect-modification by asthma status. No clear associations were found for Constances. <bold>Conclusion:</bold> Occupational exposures was linked to increased risk of COPD in ECRHS only, probably due to an older population and longer time of follow-up compared to Constances. This ExWAS set the stage for the next analytical step, assessing the joint effect of the working life-exposme.

Uppsala University (SE), National Institute of Occupational Health (NO), Uppsala University Hospital (SE), Netherlands Organisation for Applied Scientific Research (NL), University of Antwerp (BE), Université de Bordeaux (FR), Inserm (FR), University of Iceland (IS), Utrecht University (NL), European University Cyprus (CY), Aarhus University (DK), Haukeland University Hospital (NO), Aarhus University Hospital (DK), University of Cyprus (CY), Lung Institute (US), National Institute for Public Health and the Environment (NL), Bordeaux Population Health (FR), Hospital de Galdakao (ES), Province of Antwerp (BE), Monash Health (AU), Barcelona Institute for Global Health (ES), Grenoble Institute of Neurosciences (FR), Complejo Hospitalario Universitario de Albacete (ES), Melbourne Health (AU), Monash University (AU), Universidad de Huelva (ES), University of Gothenburg (SE), Université Grenoble Alpes (FR), Umeå University (SE)
Decent work and economic growth
Openalex Percentile: Top 36%
Health, Environment, Cognitive Aging
0.31
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