TRATAMENTO FARMACOLÓGICO COMO PROFILAXIA DA CEFALEIA PRIMÁRIA DO TIPO MIGRÂNEA: UMA ANÁLISE DA EFICÁCIA DOS MEDICAMENTOS

INTRODUCTION: Migraine headache is a neurological problem, varying in form and intensity, being a disruptive factor in the lives of those affected. OBJECTIVE: To present the main prophylactic pharmacological treatments for migraine, evaluating their effects and safety in comparison to other treatments. METHODS: The search was carried out through the VHL in the MEDLINE and LILACS databases, using studies from the last 5 years and with full text available in English and Portuguese. Of the 200 articles initially evaluated, 61 were selected to compose the final corpus of the study. RESULTS: 32 treatments were found available for migraine prophylaxis, with emphasis on monoclonal antibodies to the peptide related to the calcitonin gene, which reduce the frequency, duration and intensity of migraine attacks, providing a comparative improvement in relation to conventional therapies. Medications such as beta-blockers, angiotensin II antagonists, antiepileptics and onabotulinumtoxinA have also demonstrated efficacy in obtaining positive responses to migraine treatment. CONCLUSION: Evidence suggests that, due to the multiple therapeutic approaches to migraine, personalized treatment is necessary, considering the individual response to the intervention and the risk of damage in the care plan.