A RELEVÂNCIA DOS FARMACÊUTICOS NO AVANÇO E NOS DESAFIOS DO DESENVOLVIMENTO DE ANTIDEPRESSIVOS: EFICÁCIA, SEGURANÇA E ADESÃO AO TRATAMENTO.

Introduction: This article explores the crucial role of pharmacists in advancing and managing the challenges related to antidepressant development, focusing specifically on efficacy, safety, and treatment adherence. The collected data highlight how pharmacists contribute to the efficacy of antidepressants through appropriate medication selection, dose adjustment, and continuous patient monitoring. Additionally, it discusses the merit of pharmacists in ensuring patient safety, inferring the identification and management of side effects, as well as strategies to achieve better treatment adherence, which is often compromised by adverse effects and the complexity of therapeutic regimens. Methodology: Studies from 2020 to 2024 were included, employing a combination of quantitative and qualitative approaches, with data gathered from bibliographic references within the platforms: PubMed, Scielo, Lilacs, and DeCS from BVS, which provided a cohesive basis for the creation of this work. Results: The research revealed that pharmacists play a fundamental role in optimizing antidepressant efficacy and reducing associated safety risks, as well as in implementing strategies to improve treatment adherence, such as patient education and personalized support. Conclusion: Despite advancements in antidepressant development, challenges related to efficacy, safety, and adherence remain significant. Pharmacists are essential in overcoming these challenges and ensuring more effective and safe treatment for patients. Continued research is necessary to explore new management strategies and support the ongoing advancement of antidepressant pharmacotherapy.