The patient health-related quality of life (HRQoL) burden of severe asthma in Europe (SHARP CRC) for specific subgroups
<bold>Background:</bold> The HRQoL burden for patients with severe asthma is often underappreciated and little is known how this relates to age and sex. The newly validated Severe Asthma Questionnaire (SAQ) has been developed to comprehensively assess HRQoL. <bold>Aim:</bold> To assess differences in HRQoL burden of severe asthma according to age and sex. <bold>Methods:</bold> Real-word data from adults in the Severe Heterogeneous Asthma Research Collaboration Patient-centered (SHARP) registry were used in a cross-sectional multivariable linear regression, adjusting for clinical factors. The SAQ consists of a total score and 3 subscales (My Life: impact on life activities; My Mind: emotional impact; My Body: impact on extra-pulmonary symptoms and side effects). <bold>Results:</bold> Patients (N=208; 57% female, mean age 54(SD 14) yr; 79% biologic use, mean ACQ6-score 1.6(1.3)) had a mean SAQ-score of 5.1(1.6). Women reported lower scores on SAQ and My Body and patients >40yr had higher SAQ-scores across most subscales compared to <40yr (Table 1). Differences in My Body scores for women and across all outcomes for patients >60yr exceeded the MCID of 0.5. <bold>Conclusion:</bold> Compared to men, women with severe asthma report more impact on extra-pulmonary symptoms and side effects. Younger patients seem to have a poorer HRQoL across all aspects than older ones. Insight into drivers of these differences is needed to find ways to optimize HRQoL for everyone. <fig><object-id>erj;64/suppl_68/OA4576/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>
Authors
- Anneke Ten Brinke (ORCID: https://orcid.org/0000-0002-7890-1584)
- Patrícia Costa (ORCID: https://orcid.org/0000-0002-4289-7229)
- Dawn Redwood
- J. Tilley
- Sabina Škrgat (ORCID: https://orcid.org/0000-0002-0136-4733)
- Jacob K. Sont (ORCID: https://orcid.org/0000-0002-5840-0651)
- Matthew Masoli (ORCID: https://orcid.org/0000-0003-0909-0148)
- Marina Isabel Vieira Antunes Cunha (ORCID: https://orcid.org/0000-0002-5957-1903)
- Kim de Jong (ORCID: https://orcid.org/0000-0002-3948-1046)
- Simon Doe (ORCID: https://orcid.org/0000-0001-7190-9359)
- S. Hromis
- Inês Farinha (ORCID: https://orcid.org/0000-0002-6161-8547)
- Fleur L. Meulmeester (ORCID: https://orcid.org/0000-0002-8910-9795)
- Kristina Biekšienė (ORCID: https://orcid.org/0009-0008-8933-5283)
- Barbro Dahlén (ORCID: https://orcid.org/0000-0003-3803-9034)
- Dominique Hamerlijnck (ORCID: https://orcid.org/0000-0001-8464-0547)
- L. Havé (ORCID: https://orcid.org/0000-0002-9196-706X)
- Valentyna Yasinska (ORCID: https://orcid.org/0000-0002-1379-1265)
- Thomas W. Wainwright (ORCID: https://orcid.org/0000-0001-7860-2990)
- Joseph Lanario (ORCID: https://orcid.org/0000-0003-0317-9774)
- Jolita Palačionytė (ORCID: https://orcid.org/0009-0003-7329-0504)
- Peter Kopač (ORCID: https://orcid.org/0000-0001-7261-6689)
- Cláudia Chaves Loureiro (ORCID: https://orcid.org/0000-0003-0438-6126)
- Mariana Paula-Rezelj
- Ana Žaže Bertoncel
- Oksana Tenzelius
- Kathleen Bayani
Institutions
- Lithuanian University of Health Sciences (LT)
- University of Exeter (GB)
- Leiden University Medical Center (NL)
- Musgrove Park Hospital (GB)
- Ljubljana University Medical Centre (SI)
- British Lung Foundation (GB)
- Hospitais da Universidade de Coimbra (PT)
- Medisch Centrum Leeuwarden (NL)
- Svenska Örtmedicinska Institute (SE)
- University Clinic of Pulmonary and Allergic Diseases Golnik (SI)
- Newcastle upon Tyne Hospital (GB)
- Swedish Asthma and Allergy Association (SE)
- Hospital Vila Franca de Xira (PT)
- Institute for Pulmonary Diseases of Vojvodina (RS)
- University of Coimbra (PT)
- Newcastle University (GB)
- University of Plymouth (GB)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.oa4576
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00