Association between platelet and blood eosinophil counts in asthmatic adults: Results from NHANES 2011-2018

<bold>(1) Background:</bold> Currently, numerous studies have indicated platelets play an important role in asthma. However, few studies have investigated the relationship between PLT counts, MPV, and BEOS in asthmatics. <bold>(2) Methods:</bold> Our research contained 2592 asthmatics from the NHANES 2011–2018. In asthmatics, the linear regression model and XGBoost model were used to investigate the potential correlation between PLT counts, MPV, and BEOS. In addition, the trend test, the generalised additive model (GAM), and the threshold effect model were used to validate this association. In addition, subgroup analyses were conducted to determine the relationship between PLT counts, MPV, and BEOS in various populations. <bold>(3) Results:</bold> In the multivariable regression models, which adjusting all covariates, we found that BEOS increased by 0.16 (cells/uL) for each increased unit of PLT (1000 cells/uL) and decreased by 10.92 cells/uL for each increased unit of MPV (fL). Based on the GAM and threshold effect model, we discovered an inverted U-shaped association between PLT counts and BEOS in asthmatics after adjusting all covariates. When the PLT counts were below 390, there was a positive correlation with BEOS; when the PLT counts exceeded 390, there was an inverse correlation with BEOS. Additionally, we also discovered that MPV was linearly and negatively associated with BEOS. <bold>(4) Conclusion:</bold> Our study found an inverted U-shaped association between PLT counts and BEOS and linear and negative association between MPV and BEOS in asthmatic adults, which indicated that PLT counts and MPV might be somehow related to asthmatic's inflammatory status.