Homocysteine aggravates intestinal inflammation through promotion of 5-LOX and COX-2 in IBD
Hcy was found to enhance the expression of 5-LOX and COX-2 by activating NF-κB, thereby augmenting the production of LTE4 and PGE2, which ultimately exacerbates colonic inflammation in individuals with inflammatory bowel disease (IBD).
Authors
- Xiaoping Niu (ORCID: https://orcid.org/0000-0001-8824-0444)
- Pingbo Chen (ORCID: https://orcid.org/0009-0004-8171-8918)
- Chiyi He (ORCID: https://orcid.org/0000-0001-7794-9394)
- Qiao Mei (ORCID: https://orcid.org/0000-0002-0635-6564)
- Lin Li (ORCID: https://orcid.org/0000-0003-1839-8048)
- Jing Wang (ORCID: https://orcid.org/0009-0001-0183-3931)
Institutions
- Anhui Medical University (CN)
- First Affiliated Hospital of Anhui Medical University (CN)
- First Affiliated Hospital of Wannan Medical College (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s40001-024-02125-7
- Citations
- 11
- Primary Topic
- Eosinophilic Esophagitis
- Type
- article
- Field-Weighted Citation Impact
- 6.30
Funders
- Anhui University