A temperature-ultrasound sensitive nanoparticle delivery system for exploring central neuroinflammation mechanism in stroke-heart syndrome
This study introduced the key role of neuroinflammation in stroke-heart syndrome and first investigated the crucial HDAC6/SIRT1-NLRP3 circuit in this process. Heart injury secondary to stroke is mediated by neuroinflammation induced systemic inflammatory responses and sympathoexcitation. DATS/MION-LPE is a unique tool and effective therapeutic agent, which provides new insights into combinational heart and cardiac protection.
Authors
- Ziyu Zhou (ORCID: https://orcid.org/0000-0002-1626-7493)
- Minhua Jiang (ORCID: https://orcid.org/0000-0002-8729-5344)
- Zhidong Zhu
- Zhiqiang Yan (ORCID: https://orcid.org/0000-0002-8658-4048)
- Yiqing Wang (ORCID: https://orcid.org/0000-0003-0873-2831)
- Kai Huang (ORCID: https://orcid.org/0000-0002-7121-0318)
- Fan Xi
- Xiaotian Sun
- Rongrong Jiang (ORCID: https://orcid.org/0000-0002-5339-2517)
- Liewen Pang
- Milayi Jieensi
Institutions
- Second Military Medical University (CN)
- Fudan University (CN)
- Changhai Hospital (CN)
- Huashan Hospital (CN)
- East China Normal University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1186/s12951-024-02961-z
- Citations
- 7
- Primary Topic
- Biochemical effects in animals
- Type
- article
- Field-Weighted Citation Impact
- 2.29
Funders
- Natural Science Foundation of Shanghai
- National Natural Science Foundation of China