Importance of subpleural fibrosis measured by a computer-aided system in patients with interstitial pneumonias, the prospective multicenter study.

<bold>Background:</bold> Quantitative measurements of subpleural fibrosis using a Computer-Aided system (GHNC) have been linked to the presence of a histologic UIP pattern and prognosis, (Iwasawa T. Radiology, 2019). <bold>Objective:</bold> This study aimed to assess the significance of subpleural fibrosis on CT scans in predicting overall survival. Methods: We analized 749 patients (550 males, median age 70 years) diagnosed with ILD, drawn from the nationwide prospective registry of idiopathic interstitial pneumonia (JIPS Registry). Utilizing GHNC system, we measured the ratio of fibrotic lesions in the 2-mm-width subpleural region (SF2) in initial CTs (Fig 1). We compared SF2 between patients with and without UIP pattern on CT using Mann-Whitney U-tests and assessed its correlation with overall survival through Cox regression analysis. <bold>Results:</bold> The median follow-up term was 4.9 years, during which 236 patients succumbed. SF2 was significantly larger in patients exhibiting a usual interstitial pneumonia CT pattern (42.9% vs. 32.1% with and without UIP pattern, p < 0.001). After adjusting for age and sex, SF2 emerged as a significant predictor, with a hazard ratio of 1.05 (95% confidence interval 1.03-1.06, p < 0.001). <bold>Conclusion:</bold> Subpleural fibrosis, as measured on CT scans, represents an objective measure for predicting the prognosis of patients with ILD. <fig><object-id>erj;64/suppl_68/OA5473/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Authors

Institutions

Publication Details

Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.oa5473
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Importance of subpleural fibrosis measured by a computer-aided system in patients with interstitial pneumonias, the prospective multicenter study.

Hiromitsu Sumikawa, Fumikazu Sakai, Osamu Narumoto, Takeshi Johkoh et al.
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Importance of subpleural fibrosis measured by a computer-aided system in patients with interstitial pneumonias, the prospective multicenter study.

Hiromitsu Sumikawa, Fumikazu Sakai, Osamu Narumoto, Takeshi Johkoh, Yasuhiro Kondoh, Ryo Okuda, Toru Arai, Kunihiko Kobayashi, Kiminori Fujimoto, Ryoko Egashira, Hiromasa Inoue, Keisuke Tomii, Kazufumi Takamatsu, Sadatomo Tasaka, Masaki Fujita, Satoshi Wasamoto, Tomohiro Handa, Yasuhiro Gon, Akira Hebisawa, Tae Iwasawa, Masato Morita, Hiroyuki Ito, Takashi Ogura, Atsushi Miyamoto, Tomohisa Baba, Takafumi Suda, Yutaro Nakamura, Toshihiro Nukiwa
article en

Abstract

<bold>Background:</bold> Quantitative measurements of subpleural fibrosis using a Computer-Aided system (GHNC) have been linked to the presence of a histologic UIP pattern and prognosis, (Iwasawa T. Radiology, 2019). <bold>Objective:</bold> This study aimed to assess the significance of subpleural fibrosis on CT scans in predicting overall survival. Methods: We analized 749 patients (550 males, median age 70 years) diagnosed with ILD, drawn from the nationwide prospective registry of idiopathic interstitial pneumonia (JIPS Registry). Utilizing GHNC system, we measured the ratio of fibrotic lesions in the 2-mm-width subpleural region (SF2) in initial CTs (Fig 1). We compared SF2 between patients with and without UIP pattern on CT using Mann-Whitney U-tests and assessed its correlation with overall survival through Cox regression analysis. <bold>Results:</bold> The median follow-up term was 4.9 years, during which 236 patients succumbed. SF2 was significantly larger in patients exhibiting a usual interstitial pneumonia CT pattern (42.9% vs. 32.1% with and without UIP pattern, p < 0.001). After adjusting for age and sex, SF2 emerged as a significant predictor, with a hazard ratio of 1.05 (95% confidence interval 1.03-1.06, p < 0.001). <bold>Conclusion:</bold> Subpleural fibrosis, as measured on CT scans, represents an objective measure for predicting the prognosis of patients with ILD. <fig><object-id>erj;64/suppl_68/OA5473/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Nihon University (JP), Kurume University (JP), Kagoshima University (JP), Hamamatsu University (JP), Hirosaki University (JP), Saga University (JP), Tohoku University (JP), University of Kochi (JP), Kyoto University (JP), Hamamatsu University School of Medicine (JP), Kochi Medical School Hospital (JP), Fukuoka University Hospital (JP), Saku Central Hospital (JP), Kansai Rosai Hospital (JP), Kameda Medical Center (JP), Tottori University Hospital (JP), Saitama International Medical Center (JP), National Hospital Organization (JP), Kanagawa Cardiovascular and Respiratory Center (JP), Tokyo National Hospital (JP), Tosei General Hospital (JP), NHO Kinki Chuo Chest Medical Center (JP), Kobe City Medical Center General Hospital (JP), Toranomon Hospital (JP), Tottori University (JP), Kōchi University (JP), Saitama Medical University (JP)
Good health and well-being
Openalex Percentile: Top 63%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.