Investigation of sleep quality and quality of life of patients with and without obesity-hypoventilation syndrome

<bold>Background:</bold> Obesity-hypoventilation syndrome (OHS) is a combination of obesity (BMI≥30 kg/m2), daytime hypercapnia (pCO2≥45mmHg) and sleep disordered breathing (SDB), after exclusion of other disorders that may cause alveolar hypoventilation. OHS can affect both patients’ quality of life (QoL) and quality of sleep. Aim of the study is to evaluate QoL and quality sleep of obese patients (BMI≥30 kg/m2) with and without OHS. <bold>Methods:</bold> Patients were classified into 1) Group A: obese subjects without OHS and 2) Group B: subjects with OHS. All participants, referred for SDB, underwent full polysomnography and PFTs. They completed Epworth Sleepiness Scale (ESS), Fatigue Severity Scale (FSS), 5-item World Health Organization Well-Being Index (WHO-5) and Pittsburgh Sleep Quality Index (PSQI) for the assessment of sleepiness, fatigue, QoL and quality of sleep, respectively. <bold>Results:</bold> Included were 1,955 patients. The 2 groups did not differ in terms of age but several differences were observed (Table 1). No differences in ESS, FSS, WHO-5 and PSQI scores between groups were detected. <bold>Conclusions:</bold> Patients with OHS do not have worse QoL and quality of sleep compared with obese patients without OHS. <table-wrap><object-id>erj;64/suppl_68/PA878/TB1</object-id><object-id>T1</object-id><object-id>TB1</object-id><table><colgroup><col></col><col></col><col></col><col></col></colgroup><tbody><tr><td><bold>Parameters</bold></td><td><bold>Group A</bold> <bold>N=1,752</bold></td><td><bold>Group B</bold> <bold>N=203</bold></td><td><bold>p</bold></td></tr><tr><td>BMI (kg/m2)</td><td>38.12</td><td>36.58</td><td>0.001</td></tr><tr><td>FVC (% pred)</td><td>90.85</td><td>80.64</td><td>0.001</td></tr><tr><td>FEV1 (% pred)</td><td>94.78</td><td>86.09</td><td>0.001</td></tr><tr><td>pO2 (mmHg)</td><td>80.62</td><td>70.37</td><td>0.001</td></tr><tr><td>pCO2 (mmHg)</td><td>40.73</td><td>48.27</td><td>0.001</td></tr><tr><td>HCO3 (mmol/L)</td><td>26.97</td><td>30.38</td><td>0.001</td></tr><tr><td>averSpO2 (%)</td><td>92.01</td><td>89.83</td><td>0.001</td></tr><tr><td>minSpO2 (%)</td><td>76.95</td><td>71.31</td><td>0.001</td></tr><tr><td>T<90% (min)</td><td>62.88</td><td>118.78</td><td>0.001</td></tr><tr><td>ODI (/h)</td><td>35.73</td><td>45.54</td><td>0.003</td></tr><tr><td>Arousal/H</td><td>23.23</td><td>30.22</td><td>0.005</td></tr></tbody></table></table-wrap>