Clinical characteristics of severe asthma patients in Europe, according to the percentage of GDP spent on healthcare- a SHARP-CRC study

<bold>Background:</bold> Severe asthma, affects 5 to 10% of all asthma patients, but accounts for 50% of the asthma related costs. Gross domestic product (GDP) spent on healthcare affects clinical outcomes in several diseases; however, its impact on severe asthma patients is still unclear. <bold>Objectives:</bold> We aim to characterize severe asthma patients across Europe by % of the GDP spent on health care. <bold>Method:</bold> We analysed data from 3155 patients from 12 SHARP (Severe Heterogeneous Asthma Research collaboration; Patient-centred CRC) member countries, comparing those with above median GDP spent on health (GDPhigh, n=2338) to those with below median (GDPlow ,n= 817). <bold>Results:</bold> The GDPlow group included more women (p<. 001). Both groups experience exacerbations (>=2/year, 70% in both) but differ stratified by daily OCS use. The GDPlow group showed worse clinical outcomes: lower FEV1 (p< 001), more severe airflow obstruction (FEV1< 60%) (p <0.001), lower ACT (p<. 001), and more heart failure (p<. 001). Patients in GDPlow countries were treated less with LAMA (p <.001) but more often with Theophylline (p<. 001) and LTRA (p<. 001), while they had fewer biologics (79% vs. 84%) (p=. 001). Both groups had a similar daily OCS dose. However, patients in the GDPhigh countries had more OCS-related conditions (OSAS (p<. 001), osteoporosis (p<. 001) and cortical adrenal insufficiency (p<. 001). <bold>Conclusion:</bold> We showed that asthma outcomes and treatment differ significantly based on GDP spent on healthcare, suggesting policy changes are needed.

Authors

Institutions

Publication Details

Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa1248
Primary Topic
Global Health Care Issues
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Clinical characteristics of severe asthma patients in Europe, according to the percentage of GDP spent on healthcare- a SHARP-CRC study

Florin Mihălţan, Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu et al.
Global Health Care Issues
article

Clinical characteristics of severe asthma patients in Europe, according to the percentage of GDP spent on healthcare- a SHARP-CRC study

Florin Mihălţan, Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu, Marcus O. Butler, Liam Gabriel Heaney, Dóra Lúðvíksdóttir, Evangelia Fouka, Aruna T. Bansal, Georgio Walter Canonica, Florence Schleich, Εleftherios Ζervas, Cláudia Loureiro, Zsuzsanna Csoma, Vratislav Sedlák, ARNAUD AB BOURDIN, Kristina Biekšienė, Barbro Dahlén, Svetlana Sergejeva, Apostolos Bossios, Jörg D. Leuppi, Fabienne Jaun, Valentyna Yasinska, Sanja Grle Popović, Kjell Erik Julius Håkansson, Enrico Marco Heffler, David Ramos‐Barbón, Sanja Hromiš, Κonstantinos Samitas, Celeste Porsbjerg, Louis Renaud, Ineta Grisle, Sabina Skrat
article en

Abstract

<bold>Background:</bold> Severe asthma, affects 5 to 10% of all asthma patients, but accounts for 50% of the asthma related costs. Gross domestic product (GDP) spent on healthcare affects clinical outcomes in several diseases; however, its impact on severe asthma patients is still unclear. <bold>Objectives:</bold> We aim to characterize severe asthma patients across Europe by % of the GDP spent on health care. <bold>Method:</bold> We analysed data from 3155 patients from 12 SHARP (Severe Heterogeneous Asthma Research collaboration; Patient-centred CRC) member countries, comparing those with above median GDP spent on health (GDPhigh, n=2338) to those with below median (GDPlow ,n= 817). <bold>Results:</bold> The GDPlow group included more women (p<. 001). Both groups experience exacerbations (>=2/year, 70% in both) but differ stratified by daily OCS use. The GDPlow group showed worse clinical outcomes: lower FEV1 (p< 001), more severe airflow obstruction (FEV1< 60%) (p <0.001), lower ACT (p<. 001), and more heart failure (p<. 001). Patients in GDPlow countries were treated less with LAMA (p <.001) but more often with Theophylline (p<. 001) and LTRA (p<. 001), while they had fewer biologics (79% vs. 84%) (p=. 001). Both groups had a similar daily OCS dose. However, patients in the GDPhigh countries had more OCS-related conditions (OSAS (p<. 001), osteoporosis (p<. 001) and cortical adrenal insufficiency (p<. 001). <bold>Conclusion:</bold> We showed that asthma outcomes and treatment differ significantly based on GDP spent on healthcare, suggesting policy changes are needed.

Reykjavík University (IS), Queen's University Belfast (GB), Belfast Health and Social Care Trust (GB), Lithuanian University of Health Sciences (LT), Karolinska University Hospital (SE), Humanitas University (IT), University Hospital Centre Zagreb (HR), Royal College of Surgeons in Ireland (IE), Inserm (FR), University of Liège (BE), St. John's College of Nursing (US), Université de Montpellier (FR), Ljubljana University Medical Centre (SI), Hospital de Sant Pau (ES), Beaumont Hospital (IE), Bispebjerg Hospital (DK), Hospitais da Universidade de Coimbra (PT), Medisch Centrum Leeuwarden (NL), Karolinska Institutet (SE), University of Łódź (PL), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Kantonsspital Baselland (CH), Chest Diseases Hospital (KW), Riga East University Hospital (LV), Psychiatry Baselland (CH), National University Hospital of Iceland (IS), Istanbul University-Cerrahpaşa (TR), Clinica de Pneumologie Iaşi (RO), Medical University of Lodz (PL), Theological Seminary Bienenberg (CH), Institute for Pulmonary Diseases of Vojvodina (RS), Czech Society for Ornithology (CZ), Országos Korányi Tbc és Pulmonológiai Intézet (HU), University of Tartu (EE)
Decent work and economic growth
Openalex Percentile: Top 65%
Global Health Care Issues
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.