Towards disease stability in COPD management: patient perspectives

<bold>Objectives:</bold> An emerging treatment ambition for COPD is to obtain disease stability, which comprises measures such as lung function optimisation, symptom control and reductions in exacerbations. In order to provide optimal and personalised care, an understanding of patient expectations is crucial; therefore, we explored individual perceptions surrounding COPD disease stability. <bold>Methods:</bold> A patient advocacy advisory board was held in January 2024 to discuss patient perceptions of COPD management including insights into disease stability and its role as a treatment goal. <bold>Results:</bold> Advisors (N=6) described stable disease as a state where patients can achieve a “sense of normalcy” and “predictability”, which is likely to be personal to the patient. Advisors agreed that disease stability was an appropriate and ambitious treatment goal for most patients, underpinned by avoiding exacerbations and hospital visits (<bold>Figure A</bold>). Advisors prioritised quality of life, agreeing that poor disease control negatively affected this, and emphasised patient wellbeing as a key end goal (<bold>Figure B</bold>). <bold>Conclusion:</bold> Key measures of disease stability, in consideration of patient aspirations and clinical characteristics, are desirable goals for COPD management. Personalisation of treatment strategies to improve clinical outcomes underpins the achievement and maintenance of disease stability to improve quality of life for patients living with COPD. <bold>Funding:</bold> GSK <fig><object-id>erj;64/suppl_68/PA1171/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>