Rhodium-Catalyzed C–H Arylation of Indoles with Arylsilanes at Room Temperature
The Cp*Rh-catalyzed C-H arylation of indoles with arylsilanes is developed. This C-H activation transformation allows for the Rh-catalyzed indole C<sub>2</sub> arylation to overcome the limitations of requiring strong directing group assistance and high-temperature conditions, achieving a room-temperature transformation driven by a weak directing group. Cp*Rh/MeOH catalytic media are considered a key factor enabling this transformation to occur under mild conditions, and experimental studies and theoretical calculations were performed to rationalize the reaction mechanisms and the influence of methanol as a solvent in promoting the reaction.
Authors
- Yi Dong (ORCID: https://orcid.org/0000-0001-7844-7206)
- Tingting Hou (ORCID: https://orcid.org/0009-0000-1736-9419)
- Heng Xu (ORCID: https://orcid.org/0000-0002-1720-5286)
- Guang Li (ORCID: https://orcid.org/0009-0009-6105-8621)
- Xin Yang (ORCID: https://orcid.org/0009-0000-9693-1325)
- Deyu Wu
- Xin Wang (ORCID: https://orcid.org/0000-0002-6229-1945)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
Publication Details
- Journal
- The Journal of Organic Chemistry
- Published
- 2024-11-06
- DOI
- https://doi.org/10.1021/acs.joc.4c01549
- Citations
- 2
- Primary Topic
- Catalytic C–H Functionalization Methods
- Type
- article
- Field-Weighted Citation Impact
- 0.50
Funders
- Chinese Academy of Medical Sciences