Impact and burden of T2-low severe asthma: Insights from the Greek PHOLLOW Study

<bold>Background:</bold> Data on type 2 (T2)-low severe asthma (SA) is scarce due to the absence of a consistent classification system, and therapeutic needs on this population remain unmet. <bold>Objective:</bold> To assess the frequency, management strategy and burden of T2-low SA in Greece. <bold>Methods:</bold> A multicenter study conducted from March ‘22-March ‘23 in routine care settings across Greece. Based on a newly proposed classification system, patients were classified as T2-low if blood eosinophil count (BEC; cells/μL)/fractional exhaled nitric oxide (FeNO; ppb)/allergy status were <150/<25/any or <150/<50/negative or <300/<25/negative. Additional outcomes included: Asthma Control Test (ACT), Mini-Asthma Quality of Life Questionnaire, Hospital Anxiety and Depression Scale, and Work Productivity and Activity Impairment:Respiratory Symptoms questionnaire. <bold>Results:</bold> Of the 602 enrolled SA patients, 20.1% were classified as having T2-low SA. Of those, 71.1% had experienced ≥1 clinically significant exacerbations in the past 12 months, 62.8% had ACT score <20, and 22.3% were receiving biologics. Among evaluable patients, 79.5% reported impaired quality of life due to asthma, and 43.8% suffered from clinically significant emotional distress, while 30.0% of patients presented activity impairment and work productivity loss. Clinical and patient-reported outcomes were worse among patients with ACT-defined uncontrolled asthma. <bold>Conclusions:</bold> One-fifth of SA patients present with a T2-low endotype, based on our classification system. This, along with the uncontrolled disease and life impairments experienced by the patients, underscore the validity of current diagnostic tools and the need for novel therapeutic approaches in this population.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa1255
Primary Topic
Asthma and respiratory diseases
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article
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article

Impact and burden of T2-low severe asthma: Insights from the Greek PHOLLOW Study

Νikolaos Tzanakis, George Ν. Konstantinou, Maria Kipourou, Georgios Krommidas et al.
Asthma and respiratory diseases
article

Impact and burden of T2-low severe asthma: Insights from the Greek PHOLLOW Study

Νikolaos Tzanakis, George Ν. Konstantinou, Maria Kipourou, Georgios Krommidas, Dimosthenis Papapetrou, Stylianos Vittorakis, Michael P. Makris, Fotios Psarros, Εleftherios Ζervas, Dimitrios Latsios, Κonstantinos Porpodis, Nikolaos Zias, Ilias Kainis, Petros Bakakos, Eleni Tzortzaki, Petros Galanakis, Ioanna Tsiouprou, Paschalis Steiropoulos, Aikaterini Syrigou, Stelios Loukides, Κonstantinos Κostikas, Konstantinos I. Gourgoulianis, Μiltiadis Μarkatos, Marina Bartsakoulia, Ioannis Paraskevopoulos, Anastasios Palamidas, Alexia Chatzipetrou, Christina Papista, Ιlias Papanikolaou, Angeliki Damianaki, Argyris Tzouvelekis, Dimitrios Vourdas, Antonios Christopoulos, Argyrios Manikas
article en

Abstract

<bold>Background:</bold> Data on type 2 (T2)-low severe asthma (SA) is scarce due to the absence of a consistent classification system, and therapeutic needs on this population remain unmet. <bold>Objective:</bold> To assess the frequency, management strategy and burden of T2-low SA in Greece. <bold>Methods:</bold> A multicenter study conducted from March ‘22-March ‘23 in routine care settings across Greece. Based on a newly proposed classification system, patients were classified as T2-low if blood eosinophil count (BEC; cells/μL)/fractional exhaled nitric oxide (FeNO; ppb)/allergy status were <150/<25/any or <150/<50/negative or <300/<25/negative. Additional outcomes included: Asthma Control Test (ACT), Mini-Asthma Quality of Life Questionnaire, Hospital Anxiety and Depression Scale, and Work Productivity and Activity Impairment:Respiratory Symptoms questionnaire. <bold>Results:</bold> Of the 602 enrolled SA patients, 20.1% were classified as having T2-low SA. Of those, 71.1% had experienced ≥1 clinically significant exacerbations in the past 12 months, 62.8% had ACT score <20, and 22.3% were receiving biologics. Among evaluable patients, 79.5% reported impaired quality of life due to asthma, and 43.8% suffered from clinically significant emotional distress, while 30.0% of patients presented activity impairment and work productivity loss. Clinical and patient-reported outcomes were worse among patients with ACT-defined uncontrolled asthma. <bold>Conclusions:</bold> One-fifth of SA patients present with a T2-low endotype, based on our classification system. This, along with the uncontrolled disease and life impairments experienced by the patients, underscore the validity of current diagnostic tools and the need for novel therapeutic approaches in this population.

Mediterranean Agronomic Institute of Chania (GR), University of Crete (GR), Democritus University of Thrace (GR), University of Patras (GR), University of Ioannina (GR), National and Kapodistrian University of Athens (GR), Interbalkan Medical Center (GR), General University Hospital of Patras (GR), Cosmote (Greece) (GR), 401 General Military Hospital of Athens (GR), Hellenic Airforce General Hospital (GR), University Hospital of Larissa (GR), General Hospital of Drama (GR), 424 General Military Hospital (GR), Corfu General Clinic (GR), Chania General Hospital ”St. George” (GR), Athens Medical Center (GR), University Hospital of Heraklion (GR), University General Hospital Attikon (GR), Athens Naval & Veterans Hospital (GR), G. Papanikolaou General Hospital (GR), Sotiria General Hospital (GR)
Openalex Percentile: Top 72%
Asthma and respiratory diseases
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