Characteristics of chronic cough patients across Europe: A descriptive analysis from the ERS NEuroCOUGH CRC Registry

<bold>INTRODUCTION:</bold> The ERS NEuroCOUGH CRC established the first Europe-wide chronic cough (CC) patient registry comprising clinical, physiological and biological data. Here we report a descriptive analysis of clinical characteristics at baseline and 12-month follow up. <bold>Methods:</bold> Participants were recruited across 10 European cough centres. Clinical data and patient reported outcomes (cough severity VAS and cough-specific health status Leicester Cough Questionnaire; LCQ) were collected at baseline and 12-month follow up. <bold>Results:</bold> 598 participants enrolled and 126 (21%) participants completed follow up from 08/21 to 12/23; mean (SD) age 60 (12) years and 441 (74%) female. Refractory CC was the commonest cause at baseline (41%) (Table 1). Features of cough hypersensitivity were common with 569 (95%) participants reporting ≥1 triggers; median (IQR) 5 (3-7) triggers (eg cold air). Participants considered previous treatment trials ineffective; <1% reported a complete response. Vomiting, urinary incontinence and syncope were common complications (50%, 44% and 14% respectively). Cough severity and health status were moderately affected and persisted at follow up (Table 1). <bold>CONCLUSION:</bold> This first pan-European cohort of unselected patients attending cough clinics suggests participants exhibit demographics, comorbidities and cough burden consistent with previous smaller studies; over a third appear to have refractory CC. <fig><object-id>erj;64/suppl_68/PA2130/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

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Publication Details

Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa2130
Citations
2
Primary Topic
Respiratory and Cough-Related Research
Type
article
Field-Weighted Citation Impact
0.84
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article

Characteristics of chronic cough patients across Europe: A descriptive analysis from the ERS NEuroCOUGH CRC Registry

John A. Smith, Christian Domingo, Clíona McDowell, Marta Dąbrowska et al.
2 citations
Respiratory and Cough-Related Research
0.84
article

Characteristics of chronic cough patients across Europe: A descriptive analysis from the ERS NEuroCOUGH CRC Registry

John A. Smith, Christian Domingo, Clíona McDowell, Marta Dąbrowska, Sean Parker, Lorcan McGarvey, Tony Brown, Alyn H. Morice, Peter S p Cho, Surinder Singh Birring, Laurent Guilleminault, Ajit Narayanan, Péter Kardos, James H. Hull, Lieven Dupont, Jan Willem van den Berg, On Behalf Of Neurocough Investigators
article en
2 citations

Abstract

<bold>INTRODUCTION:</bold> The ERS NEuroCOUGH CRC established the first Europe-wide chronic cough (CC) patient registry comprising clinical, physiological and biological data. Here we report a descriptive analysis of clinical characteristics at baseline and 12-month follow up. <bold>Methods:</bold> Participants were recruited across 10 European cough centres. Clinical data and patient reported outcomes (cough severity VAS and cough-specific health status Leicester Cough Questionnaire; LCQ) were collected at baseline and 12-month follow up. <bold>Results:</bold> 598 participants enrolled and 126 (21%) participants completed follow up from 08/21 to 12/23; mean (SD) age 60 (12) years and 441 (74%) female. Refractory CC was the commonest cause at baseline (41%) (Table 1). Features of cough hypersensitivity were common with 569 (95%) participants reporting ≥1 triggers; median (IQR) 5 (3-7) triggers (eg cold air). Participants considered previous treatment trials ineffective; <1% reported a complete response. Vomiting, urinary incontinence and syncope were common complications (50%, 44% and 14% respectively). Cough severity and health status were moderately affected and persisted at follow up (Table 1). <bold>CONCLUSION:</bold> This first pan-European cohort of unselected patients attending cough clinics suggests participants exhibit demographics, comorbidities and cough burden consistent with previous smaller studies; over a third appear to have refractory CC. <fig><object-id>erj;64/suppl_68/PA2130/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Universitat Autònoma de Barcelona (ES), Queen's University Belfast (GB), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Fédérale de Toulouse Midi-Pyrénées (FR), King's College London (GB), Guy's and St Thomas' NHS Foundation Trust (GB), Medical University of Warsaw (PL), Manchester Academic Health Science Centre (GB), Northumbria Healthcare NHS Foundation Trust (GB), Castle Hill Hospital (GB), German Red Cross (DE), University of Manchester (GB), Auckland University of Technology (NZ), MRC Clinical Trials Unit at UCL (GB), Manchester University NHS Foundation Trust (GB), Corporació Sanitària Parc Taulí (ES), Asceneuron (Switzerland) (CH), Isala (NL), Institut des Maladies Métaboliques et Cardiovasculaires (FR), King's College Hospital (GB), NIHR Manchester Biomedical Research Centre (GB), Hull York Medical School (GB), KU Leuven (BE)
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Openalex Percentile: Top 23%
Respiratory and Cough-Related Research
0.84
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