Lifestyle Influence on Spirometry in Survivors of Childhood Acute Lymphoblastic Leukemia: A Comparative Study

Despite high rates of survival following Acute Lymphoblastic Leukemia (ALL), this study underscores the importance of addressing persistent health challenges. It highlights the vital role of the healthcare system in promoting well-being consistent with healthy peer norms. Through a comparative analysis with a control group our study aims to unveil insights into potential risk factors and their impact on lung function measured by spirometry. Conducted between February 2019 and March 2024, this national cross-sectional study explores comparative within the NOPHO ALL2008 cohort and a matched control group (Andrés-Jensen et al., 2021). Using spirometry data and selected questionnaire responses, the study assesses various factors, such as physical activity, age at diagnosis, BMI, and fatigue scores, considering their potential impact on treatment-related sequelae on lung function measured by spirometry. The study included N=365 participants who has conducted (>1 spirometry with reversibility) divided in two age groups: 4-14.9 years, N=310 and 15-17,9 years N=55. The preliminary t-test analyses reveal no significant difference in self report fatigue scores between young controls and their parents (p = 0.86) or between young controls and young survivors (p=0,37). However, notable distinctions emerge between young survivors and their parents (p = 0.014) and between parental report of survivors and controls (p = 0.036). Children in the control group had a mean fatigue score of 81.51 (SD = 10.73), while survivors had a mean fatigue score of 69.68 (SD = 17.35). Initial findings reveal diverse fatigue in child survivors and prompts further exploration into survivorship impact.