Handgrip strength and cognitive function among older adults with COPD

<bold>Background:</bold> The predictive value of handgrip strength for cognitive decline is recognized, yet its association with cognitive function in older adults living with chronic obstructive pulmonary disease (COPD) underexplored, despite the high prevalence of cognitive impairment in this population. Therefore, this study aimed to investigate this relationship using nationally-representative community-dwelling older adults with COPD. <bold>Methods:</bold> This cross-sectional analysis utilized data from the National Health and Nutrition Examination Survey 2011-2014. The study population consisted of older adults aged ≥ 60 years with self-reported COPD. Handgrip strength, measured using the Takei Digital Grip Strength Dynamometer, and cognitive function, assessed via Animal Fluency and Digit Symbol Substitution tests, were examined. Multiple linear regression models adjusted for covariates. <bold>Results:</bold> This study included 298 adults with COPD, with 43% men and a mean age of 70 years. The average handgrip strength was 29.97 kg, with average Animal Fluency and Digit Symbol Substitution Test scores of 18.11 and 49.31, respectively. Multivariate adjusted models revealed a significant association between handgrip strength and the Animal Fluency test (b = 0.13, p < 0.05, 95% CI 0.02, 0.23), but not the Digit Symbol Substitution test (b = 0.34, p = 0.09). <bold>Conclusions:</bold> Our findings suggest that stronger handgrip strength is linked to better cognitive performance in individuals with COPD, underscoring the potential benefit of interventions targeting physical function to enhance cognitive outcomes in this population.