Predictors of cough in chronic lung disease

<bold>Introduction</bold> Chronic cough (CC, >8weeks) is common and impactful in chronic lung diseases (CLD). We investigated the severity and predictors of CC in CLD. <bold>Methods:</bold> Consecutive patients with asthma, COPD, bronchiectasis, ILD and sarcoidosis were recruited from specialist clinics and compared with refractory/unexplained CC (RCC). Assessments included cough severity (VAS), cough-specific health status (LCQ), triggers: cough hypersensitivity questionnaire (CHQ), objective cough frequency (CF; Leicester Cough Monitor), depression (PHQ9) and anxiety (GAD7). Significant (p<0.1) univariate predictors of CC in CLD were evaluated with multivariate (MV) logistic regression. <bold>Results:</bold> CC was common (53-86%) in participants with CLD (n=151), and moderate in severity (Table). CLD participants with CC reported more cough triggers than those without CC; median (IQR) CHQ scores 11 (7-14) vs 4 (2-8) (p<0.01). CLD participants with CC had less severe CF, VAS and LCQ scores, and fewer triggers than RCC (all p<0.01). CLD participants with CC had worse nasal symptoms, anxiety and depression than those without (all p<0.02). Only GAD7 was a predictor of CC in MV analysis; OR (95%CI) 1.11 (1.01-1.24) (Table). <bold>Conclusion:</bold> Chronic cough (CC) is common and impactful in CLD. Only anxiety was an independent predictor of CC in CLD. Participants with CC had heightened triggers, consistent with cough hypersensitivity, which needs further study. ERS NeuroCOUGH CRC site-King’s <fig><object-id>erj;64/suppl_68/PA2129/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>