Trends of the invasive pneumococcal disease in a hospital in Madrid, 2007- 2023.

<bold>Introduction:</bold> Invasive Pneumococcal Disease (IPD) is a major cause of mortality and morbidity. New vaccines play a major role in its evolution. The aim of this study is to analyse the evolution of the IPD and the vaccines impact. <bold>Material and methods:</bold> Retrospective observational study including patients over 18 years diagnosed with IPD between 2007 and 2023 in Hospital Alcorcón Fundation. <bold>Results:</bold> 365 cases were reported, 55.9% male. 54.9% were over 65 years. The mortality rate is 13.7% and is significantly higher in those over 65 and active smokers. No association was observed between mortality and other comorbidities. Serotype 8 accounted for 17.3% of cases, there is an increase of serotype 8 since 2007 and a decrease of the incidence of serotypes included in the 13-valent vaccine (PCV13) (Figure 1). 88.5% patients had an indication for a vaccination, only 9% were vaccinated according to the recommended pattern. COPD patients have a significantly higher correct vaccination rate (17.4%). <bold>Conclusions:</bold> Active smoking increases IPD mortality. Immunisation with conjugate vaccines decreases the incidence of IPD due to serotypes included in those vaccines. It is essential to implement correct vaccination patterns. <fig><object-id>erj;64/suppl_68/PA2202/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>