The clinical impact of obtaining a single acceptable gas transfer manoeuvre

<bold>Introduction:</bold> The single-breath gas transfer (SBGT) test is routinely used in clinical practice. Both ARTP 2020 and ATS/ERS 2017 guidelines, recommend achieving 2 acceptable and reproducible results, with the mean being reported. It is unknown if obtaining 1 acceptable manoeuvre is sufficient, and the clinical impact of this. <bold>Methods:</bold> 200 patients from June 2023 who performed the SBGT test from the following clinical specialities were reviewed: Interstitial Lung Disease, Pulmonary Vascular Disease, Oncology and Lung Defence. Testing was conducted using Vyaire equipment in accordance with ARTP guidelines. A one-way ANOVA was used to assess differences, and a chi-squared test to assess for changes in grading severity between acceptable manoeuvres. Sub-analyses were conducted to review differences between clinical specialities and spirometry patterns. <bold>Results:</bold> 161 patients achieved ≥2 acceptable results, with 138 and 155 meeting ARTP and ERS reproducibility criteria respectively. Figure 1 shows the differences and number of ARTP and ERS grading severity changes between acceptable manoeuvres and the reported results. All results were comparable and non-significant when accounting for clinical speciality or spirometry pattern. <fig><object-id>erj;64/suppl_68/PA2597/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> <bold>Conclusion:</bold> In 86% of cases, one acceptable manoeuvre provided the clinical information required. There were negligible differences between acceptable SBGT manoeuvres, regardless of clinical speciality and spirometry pattern.