COPD and lung function reduction affect the brain cortical structure: A Mendelian randomization study

Chronic obstructive pulmonary disease (COPD) has been associated with alterations in brain cortical structure, but causality remains unclear. This study utilizes Mendelian randomization (MR) to investigate the causal effects of genetically predicted COPD on cortical surface area (SA) and cortical thickness (TH). Additionally, we assess the causal association between lung function indices (FEV1, FVC, FEV1/FVC) and brain cortical SA/TH in individuals without COPD. The Inverse-variance weighted (IVW) method and sensitivity tests were employed to assess heterogeneity and pleiotropy.COPD shows potential causal effects on brain cortical specifications, including pars orbitalis, cuneus, and inferior parietal gyrus. Genetic predicated lung function indices (FEV1, FVC, FEV1/FVC) also exhibit causal effects on various brain cortical structures, influencing a total of 15 functional specifications. Our findings provide insights into the causal relationships between COPD, lung function, and brain cortical structure, enhancing understanding of the impact of respiratory health on brain health. <fig><object-id>erj;64/suppl_68/PA2970/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>