Risk factors for Obstructive Sleep Apnoea (OSA) in Indian patients: Results from Sleep- Apnoea Indian Registry (S-AIR)

<bold>Objectives:</bold> To create a national registry of patients referred for diagnosis of OSA to help understand risk factors and phenotypes in Indian population <bold>Methods:</bold> A multicentre, prospective, observational cohort study (CTRI/2018/04/013320) from 18 Indian centres, funded by the Indian Chest Society. Adult patients (more than 18 years) referred for evaluation of OSA and consenting to take part were included. They undertook STOP-BANG, Epworth Sleepiness Scale and Polysomnography /Home Sleep Study test (level 1,2,3). <bold>Results:</bold> Between July 2018 and November 2021, the study enrolled 1841 cases (1443 with OSA and 398 without OSA) with a mean age of 54 years (70% men). The mean Body Mass Index (BMI) was 31.4. 98% patients belonged to the upper/middle socio economic groups. Patients with OSA had a higher neck circumference (P =0.001), and BMI (P=0.001). They were also more sleepy (ESS score 10.8 v 7.5, P<0.001). However, STOP BANG was not discriminatory. Incidence of hypertension (~44%), diabetes (23%), heart disease (8%) depression (11%) was not different. <bold>Conclusion:</bold> Indian patients with OSA are obese (BMI>25) and have higher neck circumference like their counterparts from the west. Higher/middle socio-economic class is associated with referral for OSA assessment as obesity is more prevalent along with their ability to pay. With metabolic syndromes presence at a lower BMI, STOP-BANG is less discriminatory than neck circumference. This needs to be considered when evaluating Asian patients across the world. <table-wrap><object-id>erj;64/suppl_68/PA2686/TB1</object-id><object-id>T1</object-id><object-id>TB1</object-id><table><colgroup><col></col><col></col><col></col><col></col></colgroup><tbody><tr><td>VARIABLES</td><td>WITH OSA</td><td>WITHOUT OSA</td><td>P VALUE</td></tr><tr><td>Total AHI</td><td>44.5</td><td>3</td><td>0.001</td></tr><tr><td>ESS</td><td>10.8</td><td>7.5</td><td>0.001</td></tr><tr><td>BMI</td><td>32.5</td><td>28.6</td><td>0.001</td></tr><tr><td>Neck Size</td><td>42</td><td>36</td><td>0.001</td></tr><tr><td>Waist Size</td><td>101</td><td>98</td><td>NS</td></tr><tr><td>STOP BANG</td><td>5.3</td><td>4.6</td><td>NS</td></tr></tbody></table></table-wrap>