Treatable features in decompensated COPD: network analysis

<bold>Introduction:</bold> The main objective of the study was to describe the prevalence of the different treatable traits (TT) in a cohort of COPD patients. <bold>Methods:</bold> Prospective observational study with a longitudinal design. Patients over 40 years of age, with a diagnosis of COPD who required hospital admission for ECOPD were included. In all cases the presence of TT was studied by means of clinical history, pulmonary function tests, biomarkers and thoracic computed tomography (CT). A descriptive analysis was performed using network analysis and the association between TT was evaluated using Spearman's rank correlation coefficient. <bold>Results:</bold> A total of 165 patients were included. The most frequent TT was the presence of CRP>10mg/L, which was observed in 113 (69.8%) cases, followed by a PaO2 below 60 mmHg in 71 (45.5%) patients. An acute fall in FEV1>20% was observed in less than half of the patients (47.1%). In the network analysis, a significant association was observed (Rho between different TTs of the respiratory and cardiovascular domains). A high rate of association was also detected between the parameters of inflammation and bacterial infection(Figure 1). <bold>Conclusions:</bold> There is a significant association between the cardiovascular and respiratory domain. Less than half of the patients present a significant worsening of expiratory airflow limitation during exacerbation. <fig><object-id>erj;64/suppl_68/PA3036/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>