Characteristics of severe asthma patients requiring ICU treatment across the SHARP CRC

<bold>Background-aim:</bold>Limited data exist for patients with severe asthma who require intensive care unit (ICU) treatment. We aim to address this gap. <bold>Methods:</bold>We analyzed 3,155 patients from 12 SHARP CRC (Severe Heterogeneous Asthma Research Collaboration, Patient-centered Clinical Research Collaboration) countries, stratified by their ICU admission history (ever vs never). <bold>Results:</bold>By country, ICU admissions ranged from 3.1% to 20%. More patients in the ICU-ever group had adult-onset asthma (p<0.001) and increased asthma duration (p<0.001,fig.1A,1B). The ICU-ever group included more patients with ≥2 exacerbations in the previous year despite daily oral corticosteroids (OCS), increased theophylline use and worse pre-bronchodilation (BD) FEV1 (all p<0.001, fig.1C-1E). Regarding biologics, no differences were found in anti-IgE or anti-IL-5/5Ra use; the ICU-never group had more patients on dupilumab (6.7 vs 11%,p=0.026), while biological switch was higher in the ICU-ever group (21 vs 15%,p=0.026). The ICU-ever group had a higher prevalence of OCS-related conditions (osteoporosis and cortical adrenal insufficiency, both p<0.001), while nasal polyposis was higher in the non-ICU group, p<0.001 (fig.1F). <bold>Discussion:</bold>Patients with a history of ICU admission due to asthma have distinct characteristics, with high OCS burden, poor lung function and OCS-related comorbidities, which need to be considered in our clinical and therapeutic approach. <fig><object-id>erj;64/suppl_68/PA3089/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Authors

Institutions

Publication Details

Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa3089
Primary Topic
Asthma and respiratory diseases
Type
article
Field-Weighted Citation Impact
0.00
Controls
|||
ALL TIME
JAN
FEB
MAR
APR
MAY
JUN
JUL
AUG
SEP
OCT
article

Characteristics of severe asthma patients requiring ICU treatment across the SHARP CRC

Florin Mihălţan, Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu et al.
Asthma and respiratory diseases
article

Characteristics of severe asthma patients requiring ICU treatment across the SHARP CRC

Florin Mihălţan, Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu, Marcus O. Butler, Sabina Škrgat, Evangelia Fouka, Aruna T. Bansal, Florence Schleich, Εleftherios Ζervas, Zsuzsanna Csoma, Vratislav Sedlák, Kristina Biekšienė, Barbro Dahlén, Svetlana Sergejeva, Apostolos Bossios, Fabienne Jaun, Valentyna Yasinska, Sanja Grle Popović, Kjell Erik Julius Håkansson, Sanja Hromiš, Celeste Porsbjerg, Ineta Grisle
article en

Abstract

<bold>Background-aim:</bold>Limited data exist for patients with severe asthma who require intensive care unit (ICU) treatment. We aim to address this gap. <bold>Methods:</bold>We analyzed 3,155 patients from 12 SHARP CRC (Severe Heterogeneous Asthma Research Collaboration, Patient-centered Clinical Research Collaboration) countries, stratified by their ICU admission history (ever vs never). <bold>Results:</bold>By country, ICU admissions ranged from 3.1% to 20%. More patients in the ICU-ever group had adult-onset asthma (p<0.001) and increased asthma duration (p<0.001,fig.1A,1B). The ICU-ever group included more patients with ≥2 exacerbations in the previous year despite daily oral corticosteroids (OCS), increased theophylline use and worse pre-bronchodilation (BD) FEV1 (all p<0.001, fig.1C-1E). Regarding biologics, no differences were found in anti-IgE or anti-IL-5/5Ra use; the ICU-never group had more patients on dupilumab (6.7 vs 11%,p=0.026), while biological switch was higher in the ICU-ever group (21 vs 15%,p=0.026). The ICU-ever group had a higher prevalence of OCS-related conditions (osteoporosis and cortical adrenal insufficiency, both p<0.001), while nasal polyposis was higher in the non-ICU group, p<0.001 (fig.1F). <bold>Discussion:</bold>Patients with a history of ICU admission due to asthma have distinct characteristics, with high OCS burden, poor lung function and OCS-related comorbidities, which need to be considered in our clinical and therapeutic approach. <fig><object-id>erj;64/suppl_68/PA3089/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Lithuanian University of Health Sciences (LT), Karolinska University Hospital (SE), University Hospital Centre Zagreb (HR), Royal College of Surgeons in Ireland (IE), University of Liège (BE), St. John's College of Nursing (US), Ljubljana University Medical Centre (SI), Beaumont Hospital (IE), Bispebjerg Hospital (DK), Medisch Centrum Leeuwarden (NL), Karolinska Institutet (SE), University of Łódź (PL), Kantonsspital Baselland (CH), Riga East University Hospital (LV), Psychiatry Baselland (CH), Istanbul University-Cerrahpaşa (TR), Clinica de Pneumologie Iaşi (RO), Medical University of Lodz (PL), Swedish Asthma and Allergy Association (SE), Institute for Pulmonary Diseases of Vojvodina (RS), Czech Society for Ornithology (CZ), Országos Korányi Tbc és Pulmonológiai Intézet (HU), Sotiria General Hospital (GR), University of Tartu (EE)
Good health and well-being
Openalex Percentile: Top 72%
Asthma and respiratory diseases
DOISourceOpenAlex
AI Navigator

Ask Laika to Summarize, Analyze, and Connect papers live on the map.

Summarize Papers & Methodologies

Extract key findings, datasets, and comparative methods across publications.

Benchmark Rankings & Visual Analytics

Rank top research institutions, authors, funders, topics, and journals by Field-Weighted Citation Impact (FWCI) and paper volume with instant charts.

Connect Distant Disciplines

Bridge topological clusters on the map to find hidden collaborative intersections.