Lung Cancer Burden in the SPIROMICS Cohort.

COPD is associated with an increased risk of lung cancer (LC). We sought to evaluate the morbidity and mortality from LC and predictors of LC development in SPIROMICS, an observational cohort study of healthy controls (n=202) and participants with >20 pack-year tobacco exposure either with preserved spirometry (TEPS) (n=941) or COPD (n=1830). Participants enrolled between 2010-2015 have been followed for an average of 7.6 (0.0-11.2) years with 5 in-person visits and quarterly phone calls. Vital status was obtained from the National Death Index (NDI). LC morbidity was assessed from participant-reported data collected during in-person visits. LC was considered the cause of death if it was the primary or underlying etiology, reported as ICD10 codes C33-34. Of 2973 participants, none reported LC at baseline. During the follow up, 158 (5.3%) reported LC. Based on NDI, 848 (28.5%) had died. LC was the cause of death in 93 (10.9%) participants. The majority of LC cases (46.8%) were those enrolled as GOLD Stage 2, with higher prevalence of LC in TEPS than in GOLD 1. Participants with LC were older, had more tobacco pack-years, positive LC family history, and were more often diagnosed with COPD and cardiovascular disease. In a multivariate analysis adjusted for age, race, sex, smoking status and pack-years, BMI, FEV1 and follow up time, LC was associated with worse small airway disease, PRMfSAD, (ß=0.001, P=0.04) but not emphysema. We report significant LC morbidity and mortality in the SPIROMICS cohort and identify PRMfSAD as a predictor associated with LC development. On a larger scale, our extensively bio-profiled longitudinal cohort largely composed of heavy smokers may provide substantial insight into early predictors and biomarkers of LC.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa3011
Primary Topic
Global Cancer Incidence and Screening
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article
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article

Lung Cancer Burden in the SPIROMICS Cohort.

Fereidoun G. Abtin, Lori A. Bateman, Russell Paul Bowler, Jill Ohar et al.
Global Cancer Incidence and Screening
article

Lung Cancer Burden in the SPIROMICS Cohort.

Fereidoun G. Abtin, Lori A. Bateman, Russell Paul Bowler, Jill Ohar, Igor Barjaktarević, Victor E. Ortega, Surya Prakash Bhatt, Jeffrey L. Curtis, Nadia Hansel, Donald P. Tashkin, Jerry A. Krishnan, Prescott G. Woodruff, Alejandro P. Comellas, Eric P. Hoffman, Christopher B. Cooper, Robert Paine, David Couper, Fernando J. Martínez, Meilan Han, Steven M. Dubinett, R. Graham Barr, Nathaniel Marchetti, Mark Dransfiend
article en

Abstract

COPD is associated with an increased risk of lung cancer (LC). We sought to evaluate the morbidity and mortality from LC and predictors of LC development in SPIROMICS, an observational cohort study of healthy controls (n=202) and participants with >20 pack-year tobacco exposure either with preserved spirometry (TEPS) (n=941) or COPD (n=1830). Participants enrolled between 2010-2015 have been followed for an average of 7.6 (0.0-11.2) years with 5 in-person visits and quarterly phone calls. Vital status was obtained from the National Death Index (NDI). LC morbidity was assessed from participant-reported data collected during in-person visits. LC was considered the cause of death if it was the primary or underlying etiology, reported as ICD10 codes C33-34. Of 2973 participants, none reported LC at baseline. During the follow up, 158 (5.3%) reported LC. Based on NDI, 848 (28.5%) had died. LC was the cause of death in 93 (10.9%) participants. The majority of LC cases (46.8%) were those enrolled as GOLD Stage 2, with higher prevalence of LC in TEPS than in GOLD 1. Participants with LC were older, had more tobacco pack-years, positive LC family history, and were more often diagnosed with COPD and cardiovascular disease. In a multivariate analysis adjusted for age, race, sex, smoking status and pack-years, BMI, FEV1 and follow up time, LC was associated with worse small airway disease, PRMfSAD, (ß=0.001, P=0.04) but not emphysema. We report significant LC morbidity and mortality in the SPIROMICS cohort and identify PRMfSAD as a predictor associated with LC development. On a larger scale, our extensively bio-profiled longitudinal cohort largely composed of heavy smokers may provide substantial insight into early predictors and biomarkers of LC.

University of Iowa (US), NetApp (United States) (US), APLA Health (US), City College of San Francisco (US), Cornell University (US), University of Utah (US), University of Michigan (US), National Jewish Health (US), University of Alabama at Birmingham (US), University of Illinois Chicago (US), University of Chicago (US), Mayo Clinic in Florida (US), Iowa City Public Library (US), Wake Forest University (US), University of Baltimore (US), Columbia University (US), Temple University (US), University of Colorado Denver (US), Philadelphia University (US)
Good health and well-being
Openalex Percentile: Top 65%
Global Cancer Incidence and Screening
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