The interplay between COPD and chronic heart failure deterioration

<bold>Background:</bold> COPD and chronic heart failure (CHF) commonly co-exist and share symptoms, which complicates disease management. It is unclear how symptom deterioration of COPD and CHF inter(re)act. <bold>Aim:</bold> Assess the interplay between COPD and CHF deterioration at group and individual level. <bold>Methods:</bold> Total daily COPD (0-7) and CHF (0-6) symptom scores, based on increased symptoms reported in 1-year daily diaries (ERJ 2019 54:1802134), were used to assess the COPD-CHF interplay at group and individual level using two mixed models. <bold>Results:</bold> 33 patients (72±8 years, 24 men (73%)) were included. Model 1 shows that, at group level, increased CHF symptom score predicts next day’s COPD symptoms (p=0.02). This was not consistently observed at individual level due to the large variation in the direction and strength of the individual-level associations (Fig 1A). Model 2 shows that, at group level, increased COPD symptom score predicts next day’s CHF symptoms (p<0.001). Less variation was observed in the direction of the model 2 individual-level associations, still, they differed in strength from no association to strong positive associations (Fig 1B). <bold>Conclusions:</bold> At group level, CHF deterioration predicts an increase in next day’s COPD symptom score as well as vice versa. Yet, at individual level, only the group-level conclusion of model 2 holds. Increased COPD symptoms thus consistently predict deterioration of CHF the next day within individual patients. <fig><object-id>erj;64/suppl_68/PA3021/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>