Characteristics of never-, switching, and persisting users of biologics for severe asthma – a SHARP-CRC study
<bold>Introduction</bold> Characteristics of patients switching biologic therapies for severe asthma are sparsely investigated. We aimed to characterize patients based on their biologic use pattern. <bold>Methods</bold> Using the SHARP (Severe Heterogeneous Asthma Research Collaboration Patient-centred) registry, patients from 11 countries were included and characteristics were stratified according to biologic use (never, switching, and persistent). <bold>Results</bold> Of 927 patients, 60%, 16%, and 24% were never, switching, and persistent users. Never users were older (mean age 57 vs53; 52), often female (66% vs 61%; 55%), and current smokers (7% vs 1%; 1%) compared to switching and persistent users. Daily OCS use and dose were more frequent/higher in switching (26%; 41%; 10mg) and persistent (29%; 42%; 5mg) compared to never users (21%; 19%; 5mg) (p=0.001). LTRA and theophylline use was higher in never users. Never users had worse lung function, and severe airway obstruction (FEV1 <60%) was seen in 31%, 16%, and 12% of never, switching, and persistent users (p<0.001). Nasal polyps and CRS were most frequent in persistent users (p<0.001). Obesity and heart failure were most common in never users (37% & 8%). <bold>Conclusion</bold> Patient characteristics vary based on biologic use patterns, with switchers exhibiting traits of both never- and persisting users. Understanding why clinicians switch biologics could aid tailoring therapy for future patients. <fig><object-id>erj;64/suppl_68/PA3938/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>
Authors
- Florin Mihălţan
- Piotr Kuna (ORCID: https://orcid.org/0000-0003-2401-0070)
- Anneke Ten Brinke (ORCID: https://orcid.org/0000-0002-7890-1584)
- Bilun Gemicioğlu (ORCID: https://orcid.org/0000-0001-5953-4881)
- Sabina Škrgat (ORCID: https://orcid.org/0000-0002-0136-4733)
- Evangelia Fouka (ORCID: https://orcid.org/0000-0003-4456-8987)
- Aruna T. Bansal (ORCID: https://orcid.org/0000-0002-7262-6534)
- Florence Schleich (ORCID: https://orcid.org/0000-0002-2678-1373)
- Εleftherios Ζervas (ORCID: https://orcid.org/0000-0001-7436-4550)
- Zsuzsanna Csoma
- Kristina Biekšienė (ORCID: https://orcid.org/0009-0008-8933-5283)
- Barbro Dahlén (ORCID: https://orcid.org/0000-0003-3803-9034)
- Svetlana Sergejeva
- Apostolos Bossios (ORCID: https://orcid.org/0000-0002-0494-2690)
- Fabienne Jaun (ORCID: https://orcid.org/0000-0002-1229-2181)
- Valentyna Yasinska (ORCID: https://orcid.org/0000-0002-1379-1265)
- Sanja Grle Popović
- Kjell Erik Julius Håkansson (ORCID: https://orcid.org/0000-0001-5804-0740)
- Sanja Hromiš (ORCID: https://orcid.org/0000-0001-6132-1551)
- Κonstantinos Samitas (ORCID: https://orcid.org/0000-0002-9921-9859)
- Celeste Porsbjerg (ORCID: https://orcid.org/0000-0003-4825-9436)
- Ineta Grisle
Institutions
- Lithuanian University of Health Sciences (LT)
- University Hospital Centre Zagreb (HR)
- University of Liège (BE)
- St. John's College of Nursing (US)
- Ljubljana University Medical Centre (SI)
- Bispebjerg Hospital (DK)
- Copenhagen University Hospital (DK)
- Medisch Centrum Leeuwarden (NL)
- Karolinska Institutet (SE)
- University of Łódź (PL)
- Kantonsspital Baselland (CH)
- Chest Diseases Hospital (KW)
- Riga East University Hospital (LV)
- Svenska Örtmedicinska Institute (SE)
- Psychiatry Baselland (CH)
- Istanbul University-Cerrahpaşa (TR)
- Clinica de Pneumologie Iaşi (RO)
- Medical University of Lodz (PL)
- Institute for Pulmonary Diseases of Vojvodina (RS)
- Országos Korányi Tbc és Pulmonológiai Intézet (HU)
- University of Tartu (EE)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.pa3938
- Primary Topic
- Asthma and respiratory diseases
- Type
- article
- Field-Weighted Citation Impact
- 0.00