Homocysteine as a multifunctional indicator of thrombophilia, endothelial dysfunction and systemic inflammation in patients with COPD

The role of homocysteine(Hc) in the genesis of COPD is not well understood. Hc may be a candidate for the role of a multifactorial marker that has a role in the most important mechanisms important in the course of COPD. The purpose of the study was to determine the role of Hc in 3 important systems important in COPD: coagulation, endothelial dysfunction and systemic inflammation. Materials and methods included 123 patients diagnosed with COPD (GOLD, 2023). Levels of Hc increase were calculated as multiples of the conventional norm. The levels of thrombophilia markers, endothelial dysfunction and systemic inflammation markers were determined in groups with varying degrees of Hc elevation. Results. Based on the determination of the levels of markers of thrombophilic tension in groups of COPD patients with varying degrees of Hc elevation, we can state the prothrombotic effect of Hc, that is, the induction of HC thrombophilia in COPD, and the greatest role in the genesis of thrombophilia is played by the hyperhomocysteinemia level above 3N. It was found that with increasing levels of Hc elevation, there was a progressive increase in the levels of von Willebrand Factor and NTproBNP, which may indicate the role of Hc as an indicator of existing deep endothelial dysfunction. It has been established that with an increase in the level of Hc in the blood, there is an increase in the systemic inflammatory response, expressed in an increase in IL-1, IL-6, IL-8, as well as TNF α with an increase in the level of COPD from 2N to 7N. <bold>Conclusion:</bold> Homocysteine is a factor important in both the coagulation system, endothelial dysfunction and systemic inflammation in COPD and may possibly play a role as an indicator of the presence of changes in these systems in COPD.