Pulmonary vascular resistance to predict one-year survival in ILD-PH
Pulmonary hypertension (PH) is a deadly complication of interstitial lung diseases (ILD). With the advent of new therapies, the need for short-term survival prognostic factors has become critical. We assessed whether the level of pulmonary vascular resistances (PVR) is a discriminating factor in one-year survival. We analyzed data of patients with ILD-PH from the French national prospective PH registry. Results are given as median [IQR]. The ability of PVR to predict one-year mortality was evaluated using the time-dependent area under the receiver operating characteristic (ROC) curve (AUC) and the associated 95% confidence interval (95%CI). N = 581 patients were included (male 78%, aged 70 years [64 – 77]). PVR were 6.8 wood units (WU) [5 – 9.5 WU]. N = 148 (25%) had PVR ≤ 5 WU, n = 208 (36%) had PVR > 5 and ≤ 8 WU and n = 214 (37%) had PVR > 8 WU. PVR were a long-term prognostic factor with a median time to death of 26.2 months [20.5 – 32.3] if PVR ≤ 5UW, 17.8 months [14.7 – 24.4] if PVR > 5UW and ≤ 8UW and 16.4 months [13.8 – 19.9] for patients with PVR > 8UW (p < 0.001). However, the PVR value is not able to discriminate patients that will die during the year from those that will survive (AUC of 0.56 [0.51 – 0.61]). PVR insufficiently predicts one-year survival in ILD-PH. Additional studies are required to enhance our ability to predict short-term outcomes in this life-threatening condition. <fig><object-id>erj;64/suppl_68/PA3417/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>
Authors
- Olivier Sanchez (ORCID: https://orcid.org/0000-0003-1633-8391)
- Bouchra Lamia (ORCID: https://orcid.org/0000-0003-2113-9813)
- Laurent Bertoletti (ORCID: https://orcid.org/0000-0001-8214-3010)
- Nicolas Lamblin (ORCID: https://orcid.org/0000-0003-3754-1241)
- Bruno Degano (ORCID: https://orcid.org/0000-0003-1644-7264)
- Delphine Horeau-Langlard
- Marianne Riou (ORCID: https://orcid.org/0000-0001-6807-8582)
- Vincent Cottin
- V. Valentin (ORCID: https://orcid.org/0000-0002-4870-3923)
- Ségolène Turquier (ORCID: https://orcid.org/0000-0001-5894-4491)
- Rémi Diesler (ORCID: https://orcid.org/0000-0003-0746-357X)
- S. Palat (ORCID: https://orcid.org/0000-0003-2292-6253)
- Ari Chaouat (ORCID: https://orcid.org/0000-0001-6056-202X)
- Martine Reynaud‐Gaubert (ORCID: https://orcid.org/0000-0002-5236-5867)
- Sabrina Zeghmar
- D. Raharison
- Athénaïs Boucly (ORCID: https://orcid.org/0000-0001-6246-5557)
- ARNAUD AB BOURDIN (ORCID: https://orcid.org/0000-0002-4645-5209)
- Cécile Tromeur (ORCID: https://orcid.org/0000-0001-9161-7521)
- Laurence Rottat
- Hilario Nunès (ORCID: https://orcid.org/0000-0003-2896-7347)
- Fabien Subtil (ORCID: https://orcid.org/0000-0003-1955-2019)
- Mathilde Duprez
- Thomas Lacoste-Palasset (ORCID: https://orcid.org/0000-0003-3543-6675)
- David Montani (ORCID: https://orcid.org/0000-0002-9358-6922)
- Marc Humbert (ORCID: https://orcid.org/0000-0003-0703-2892)
- Olivier Sitbon (ORCID: https://orcid.org/0000-0002-1942-1951)
- François Picard (ORCID: https://orcid.org/0000-0003-4426-940X)
- Philippe Bonniaud
- Claire Dauphin
- Élise Artaud-Macari
- Emmanuel Bergot (ORCID: https://orcid.org/0000-0002-8097-8820)
- Elise Noël‐Savina
- Pascal Magro (ORCID: https://orcid.org/0000-0002-0650-9356)
- Kaïs Ahmad
- Clément Boissin
- Sébastien Quétant
- Ana Nieves-Martinez
- Charlotte Loriau
Institutions
- Université Claude Bernard Lyon 1 (FR)
- Inserm (FR)
- Université de Bretagne Occidentale (FR)
- Université Paris Cité (FR)
- Université Paris-Saclay (FR)
- Centre Hospitalier Universitaire de Grenoble (FR)
- Centre Hospitalier Universitaire de Bordeaux (FR)
- Centre Hospitalier Universitaire de Lille (FR)
- Centre Hospitalier Universitaire de Nantes (FR)
- Centre Hospitalier Universitaire de Toulouse (FR)
- Sorbonne Université (FR)
- Centre Hospitalier Universitaire de Besançon (FR)
- Université Sorbonne Paris Nord (FR)
- Centre Hospitalier Universitaire de Montpellier (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Centre Hospitalier Régional et Universitaire de Nancy (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Hôpital Européen (FR)
- Centre Hospitalier Universitaire de Caen Normandie (FR)
- Hôpital Nord (FR)
- CHU Dijon Bourgogne (FR)
- Centre Hospitalier Universitaire de Limoges (FR)
- Groupe Hospitalier du Havre (FR)
- Centre Hospitalier Universitaire de Clermont-Ferrand (FR)
- Hôpital Avicenne (FR)
- Hôpital Louis Pradel (FR)
- Centre Hospitalier Universitaire de Rouen (FR)
- Centre Hospitalier Universitaire de Saint-Étienne (FR)
- Bicêtre Hospital (FR)
- Hôpital Civil, Strasbourg (FR)
- Université de Rouen Normandie (FR)
- Université Jean Monnet (FR)
- Université Grenoble Alpes (FR)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.pa3417
- Primary Topic
- Pulmonary Hypertension Research and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00