Clinical characteristics of patients one year after hospitalisation for viral lower respiratory tract disease by viral aetiology: A descriptive US claims analysis

<bold>Background:</bold> Severe viral lower respiratory tract disease (LRTD) has been linked to long-term impacts on health status, but it is unknown if this varies by viral aetiology. <bold>Aims:</bold> To describe clinical characteristics of US adults hospitalised with viral LRTD who survived one year after hospitalisation by viral aetiology. <bold>Methods:</bold> Clinical and treatment characteristics in those hospitalised with viral LRTD during 2022 were analysed by viral aetiology one year after hospitalisation versus the prior year using Optum’s de-identified Clinformatics^® Data Mart database. <bold>Results:</bold> Median (IQR) CCI score was 3 (1-6) across different viruses. Readmission was: 36% for coronavirus, 36% for influenza, 38% for respiratory syncytial virus, 42% for metapneumovirus and 44% for multi-viral aetiology. Average time to readmission across viral aetiologies: 112-151 days. One year after hospitalisation, 9-14% of patients had a new diagnosis, including 9-16% for anxiety, 11-20% for depression, 8-14% for lung complications and 10-15% for kidney dysfunction (Figure). 14-19% of patients had a new prescription for a systemic corticosteroid and 12-16% had one for an opioid. <bold>Conclusions:</bold> There is an increase in disease burden in the one year after hospitalisation for viral LRTD, with similar readmission frequency, time to readmission and new diagnosis frequency across all viruses. <fig><object-id>erj;64/suppl_68/PA3303/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>