Eosinophilic Granulomatosis with Polyangiitis: Clinical Suspicion Red Flags Identification by a Systematic Literature Review and Multidisciplinary Expert Consensus

<bold>Background:</bold> Eosinophilic Granulomatosis with Polyangiitis (EGPA) is a rare ANCA-associated vasculitis, histologically characterized by eosinophilic tissue infiltration, necrotizing vasculitis, and eosinophil-rich granulomatous inflammation <bold>Objective:</bold> To identify a comprehensive and evidence-based list of signs, symptoms and laboratory parameters reported to precede the diagnosis of EGPA that can be used as red flags <bold>Method:</bold> A systematic literature search identified signs, symptoms and laboratory abnormalities assessed by a consensus of a nominal multidisciplinary group of experts. Red flags identified as suspicion signals were categorized to facilitate evidence-based clinical review of patients with eosinophilia <bold>Results:</bold> 382 records were reviewed, 214 items were assessed and 40 red flags were identified as relevant to raise a suspicion of EGPA. Using these 40 red flags, an evidence-based clinical checklist tool was developed for use in routine practice to raise EGPA suspicion in patients with eosinophilia <bold>Conclusion:</bold> Systematic literature review and multidisciplinary expert consensus rating has enabled, for the first time, the identification of a comprehensive red flags to be used to raise a suspicion for EGPA, providing clinicians with an evidence-based checklist tool that can be integrated into their routine practice <bold>Funding:</bold> GSK <bold>Note:</bold> This is an encore submission of the American College Rheumatology original abstract.