Clinical and serological profiles of 802 Allergic Broncho Pulmonary Aspergillosis (ABPA) patients across 23 centers in India
<bold>Introduction:</bold> We aimed to evaluate the diagnostic practices of ABPA by physicians from multiple centers across India. <bold>Methods:</bold> Pulmonologists from 23 centers within the Respiratory Research Network (RRN) participated in this observational registry study. Patients were categorized into 3 groups based on International Society for Human and Animal Mycology (ISHAM) 2021 criteria; Group 1: meeting ISHAM criteria, Group 2: meeting partial ISHAM criteria (HRCT positive or serological positive in any 2 parameters), and Group 3: physician diagnosed, not meeting ISHAM criteria. <bold>Results:</bold> Out of 802 patients, 37.2% (299) were in group I, 50.2% (403) in group II, and 12.4% (100) in group III. 97.2% were non-smokers. Differences between 3 groups are presented in the Table <table-wrap><object-id>erj;64/suppl_68/PA4018/T1</object-id><object-id>T1</object-id><object-id>t1</object-id><table><colgroup><col></col><col></col><col></col><col></col></colgroup><tbody><tr><td>Variables</td><td> Group I (N=299) </td><td> Group II (N=403) </td><td> Group III (N=100) </td></tr><tr><td><bold>CLINICAL FINDINGS</bold></td><td>Percent</td><td>Percent</td><td>Percent</td></tr><tr><td>History of Asthma</td><td>89.7%</td><td>93.3%</td><td>97.0%</td></tr><tr><td>Presence of Haemoptysis and brownish-black mucus plugs</td><td>33.8%</td><td>13.6%</td><td>4.0%</td></tr><tr><td>History of inappropriate ATT intake</td><td>24.1%</td><td>7.2%</td><td>4.0%</td></tr><tr><td>Presence of comorbidity</td><td>36.8%</td><td>43.9%</td><td>31.0%</td></tr><tr><td>History of relapse</td><td>30.4%</td><td>19.6%</td><td>9.0%</td></tr><tr><td><bold>SEROLOGICAL FINDINGS</bold></td><td>Median (Q1,Q3)</td><td>Median (Q1,Q3)</td><td>Median (Q1,Q3)</td></tr><tr><td>Total IgE (IU/mL)</td><td>2500 (1399, 5606)</td><td>1862 (1000, 3200)</td><td>1020 (538, 2016)</td></tr><tr><td>Serum A.fumigatus IgE (kUA/L)</td><td>15.5 (1.5, 32)</td><td>1.8 (0.5, 16.1)</td><td>0.19 (0.08, 0.30)</td></tr><tr><td>Serum A.fumigatus IgG (mgA/L)</td><td>61.4 (32.5, 131.9)</td><td>20.8 (9.5, 43.5)</td><td>18.7 (9.0, 39.7)</td></tr><tr><td>Total eosinophil count (per uL)</td><td>780 (550, 1200)</td><td>372 (170, 580)</td><td>503 (319, 928)</td></tr></tbody></table></table-wrap> <bold>Conclusion:</bold> There is considerable variation in the diagnostic criteria for ABPA across India and greater awareness needs to be created about ISHAM criteria.
Authors
- Akashdeep Singh (ORCID: https://orcid.org/0000-0002-5513-8352)
- Praveen Valsalan
- Swapnil Gadhave (ORCID: https://orcid.org/0000-0002-1551-6259)
- Babaji Ghewade (ORCID: https://orcid.org/0000-0003-1553-7268)
- Aditya Jindal (ORCID: https://orcid.org/0000-0003-2471-1686)
- Jaideep Gogtay
- Kaushik Saha (ORCID: https://orcid.org/0000-0002-7151-1268)
- Deesha Ghorpade (ORCID: https://orcid.org/0000-0002-3315-620X)
- Raja Dhar (ORCID: https://orcid.org/0000-0002-6742-5674)
- Puneet Saxena (ORCID: https://orcid.org/0000-0003-1111-1008)
- Sapna Madas (ORCID: https://orcid.org/0000-0003-0733-4436)
- Surya Kant (ORCID: https://orcid.org/0000-0001-7520-5404)
- Ruchi Dua (ORCID: https://orcid.org/0000-0002-3208-673X)
- Vishwanath Gella (ORCID: https://orcid.org/0000-0003-0866-8999)
- Sushmeeta Chhowala
- Sundeep Salvi (ORCID: https://orcid.org/0000-0003-2292-9999)
- Ritesh Agarwal (ORCID: https://orcid.org/0000-0003-2547-7668)
- Venkata Nagarjuna Maturu (ORCID: https://orcid.org/0000-0002-3679-9497)
- Devendra Kumar (ORCID: https://orcid.org/0000-0001-9516-4830)
- Abhishek Sabale
- Syamal Sarkar
- Rajendra Prasad (ORCID: https://orcid.org/0000-0001-9425-5423)
- Snehal Kulkarni
- Rennis Davis
- Mohit Agrawal
- Amit Dave
- Abhinav Chaudhary
- Prashant N. Chhajed
- Sandesh Sawant
- AR Paramez
- Pooja Bhalekar
- Sheetu Singh
- Rakesh Godra
- Suresh Ananthraj
- Mangesh Chandolkar
- Samruddhi Bhalare
Institutions
- Calcutta National Medical College and Hospital (IN)
- Amrita Institute of Medical Sciences and Research Centre (IN)
- University of Mumbai (IN)
- Patna Medical College and Hospital (IN)
- Aliah University (IN)
- Indira Gandhi Institute of Medical Sciences (IN)
- CARE Hospitals (IN)
- Maharashtra Institute of Medical Science and Research (IN)
- King George's Medical University (IN)
- Lourdes Hospital (IN)
- Dayanand Medical College & Hospital (IN)
- Jawaharlal Nehru Medical College (IN)
- M.V. Hospital and Research Centre (IN)
- Samjin Pharm (South Korea) (KR)
- Institute of Post Graduate Medical Education and Research (IN)
- Calcutta Research Group (IN)
- Sri Ramachandra Medical Centre (IN)
- Era's Lucknow Medical College and Hospital (IN)
- KM Shah Dental College and Hospital (IN)
- Education & Research Foundation (US)
- Birla Institute of Scientific Research (IN)
- Global Hospitals (IN)
- Yashoda Hospital (IN)
- Datta Meghe Institute of Higher Education and Research (IN)
- Pain Clinic of India (IN)
- Aster Medcity (IN)
- Army Hospital Research and Referral (IN)
- Rajasthan Dental College and Hospital (IN)
- All India Institute of Medical Sciences Rishikesh (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Institute of Medical Sciences (IN)
- Medical College and Hospital, Kolkata (IN)
- Jaipur National University (IN)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.pa4018
- Primary Topic
- Antifungal resistance and susceptibility
- Type
- article
- Field-Weighted Citation Impact
- 0.00