Initial data analysis of the SHARP CRC patient population reveals a large heterogeneity among European patients with severe asthma

<bold>Background-aim:</bold> The heterogeneity of patients with severe asthma in Europe necessitates real-world evidence from large cohorts to improve disease understanding and patient care. This study aims to address this gap. <bold>Methods:</bold> We analyzed 5419 patients from 13 SHARP CRC (Severe Heterogeneous Asthma Research Collaboration, Patient-centered Clinical Research Collaboration) countries (fig.1A). <bold>Results:</bold> By country, most patients (73-97%) had adult-onset asthma, were female and had disease of varying duration (fig.1B,1C). Current and ex-smokers ranged from 0-7.8% and 11-43%, respectively (fig.1D). A wide range (0-41%) of patients presented severe airway obstruction (FEV1<60%). Asthma control varied, and most patients presented ≥2 exacerbations in the previous year, despite daily oral corticosteroid (OCS) use (fig.1E), with a mean daily dose ranging from to 2-25 mg prednisolone equivalent. The use of biologics also varied widely (fig.1F). Sinonasal disease ranked highest in all countries; obesity, osteoporosis, corticoadrenal insufficiency, type 2 diabetes mellitus and bronchiectasis were also commonly reported. <bold>Conclusions:</bold> Patients with severe asthma in the SHARP CRC registry showed great heterogeneity. Most patients were female, with a long history of adult-onset asthma, affected lung function and notable differences in smoking history, asthma control, medication use and comorbidities. <fig><object-id>erj;64/suppl_68/PA4008/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa4008
Primary Topic
Asthma and respiratory diseases
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article
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article

Initial data analysis of the SHARP CRC patient population reveals a large heterogeneity among European patients with severe asthma

Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu, Liam Gabriel Heaney et al.
Asthma and respiratory diseases
article

Initial data analysis of the SHARP CRC patient population reveals a large heterogeneity among European patients with severe asthma

Piotr Kuna, Anneke Ten Brinke, Bilun Gemicioğlu, Liam Gabriel Heaney, Sabina Škrgat, Dóra Lúðvíksdóttir, Evangelia Fouka, Aruna T. Bansal, Georgio Walter Canonica, Florence Schleich, Εleftherios Ζervas, Cláudia Loureiro, Zsuzsanna Csoma, Vratislav Sedlák, ARNAUD AB BOURDIN, Kristina Biekšienė, Barbro Dahlén, Florin Dumitru Mihaltan, Svetlana Sergejeva, Apostolos Bossios, Marcus W. Butler, Jörg D. Leuppi, Fabienne Jaun, Valentyna Yasinska, Sanja Grle Popović, Kjell Erik Julius Håkansson, Enrico Marco Heffler, David Ramos‐Barbón, Sanja Hromiš, Celeste Porsbjerg, Louis Renaud, Ineta Grisle
article en

Abstract

<bold>Background-aim:</bold> The heterogeneity of patients with severe asthma in Europe necessitates real-world evidence from large cohorts to improve disease understanding and patient care. This study aims to address this gap. <bold>Methods:</bold> We analyzed 5419 patients from 13 SHARP CRC (Severe Heterogeneous Asthma Research Collaboration, Patient-centered Clinical Research Collaboration) countries (fig.1A). <bold>Results:</bold> By country, most patients (73-97%) had adult-onset asthma, were female and had disease of varying duration (fig.1B,1C). Current and ex-smokers ranged from 0-7.8% and 11-43%, respectively (fig.1D). A wide range (0-41%) of patients presented severe airway obstruction (FEV1<60%). Asthma control varied, and most patients presented ≥2 exacerbations in the previous year, despite daily oral corticosteroid (OCS) use (fig.1E), with a mean daily dose ranging from to 2-25 mg prednisolone equivalent. The use of biologics also varied widely (fig.1F). Sinonasal disease ranked highest in all countries; obesity, osteoporosis, corticoadrenal insufficiency, type 2 diabetes mellitus and bronchiectasis were also commonly reported. <bold>Conclusions:</bold> Patients with severe asthma in the SHARP CRC registry showed great heterogeneity. Most patients were female, with a long history of adult-onset asthma, affected lung function and notable differences in smoking history, asthma control, medication use and comorbidities. <fig><object-id>erj;64/suppl_68/PA4008/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

Reykjavík University (IS), Queen's University Belfast (GB), Lithuanian University of Health Sciences (LT), Karolinska University Hospital (SE), Humanitas University (IT), University Hospital Centre Zagreb (HR), Royal College of Surgeons in Ireland (IE), Inserm (FR), University of Liège (BE), University of Iceland (IS), St. John's College of Nursing (US), University of Basel (CH), Université de Montpellier (FR), Ljubljana University Medical Centre (SI), Hospital de Sant Pau (ES), Beaumont Hospital (IE), Bispebjerg Hospital (DK), Medisch Centrum Leeuwarden (NL), Karolinska Institutet (SE), University of Łódź (PL), Physiologie et Médecine Expérimentale du Coeur et des Muscles (FR), Kantonsspital Baselland (CH), Riga East University Hospital (LV), Psychiatry Baselland (CH), National University Hospital of Iceland (IS), Istanbul University-Cerrahpaşa (TR), Clinica de Pneumologie Iaşi (RO), Medical University of Lodz (PL), Swedish Asthma and Allergy Association (SE), Institute for Pulmonary Diseases of Vojvodina (RS), Czech Society for Ornithology (CZ), IRCCS Humanitas Research Hospital (IT), Országos Korányi Tbc és Pulmonológiai Intézet (HU), Sotiria General Hospital (GR), University of Tartu (EE), University of Coimbra (PT)
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Asthma and respiratory diseases
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