Clinical determinants and phenotypic evaluation of asthma in a North Indian population.

<bold>Background:</bold> Asthma, a chronic respiratory condition with diverse causes, presents a global health burden. Despite symptom management, exacerbations remain a challenge. Recognizing the various asthma phenotypes is essential for understanding the disease and developing targeted treatment strategies. <bold>Aim:</bold> We aimed to investigate the clinical determinants and phenotypic differences of asthma in a north Indian population. <bold>Methods:</bold> A cross-sectional study assessed phenotypes in 110 subjects from a North Indian tertiary care center. Their clinical characteristics related to atopy, age of asthma onset, body mass index (BMI), and lung function were evaluated for the phenotypic assessment. Ethical clearance was obtained and study was performed in accordance of approved protocol and obtaining written consent from all the study-participants. <bold>Results:</bold> Our data showed a male majority, with 70% being male and 30% female. The mean BMI was 23.6 ± 2.45 kg/m2. The majority (65%) of the asthma patients were classified as having the bronchial asthma (BA) with allergic rhinitis phenotype, and these patients typically had a history of atopy. The age group of 18-35 years (70%) had an earlier disease onset and exhibited mild airflow limitation in lung function tests. Conversely, the BA-smoker and BA-obesity phenotypes (35%) observed in the 40-50year age group had no atopic history and presented with a later disease onset and mild to moderate lung function. <bold>Conclusion:</bold> Distinct asthma phenotypes influence disease characteristics. Phenotype-based management strategies hold promise for targeted treatment and improved outcomes.