HRCT and Chest X-ray findings in 802 Allergic Broncho Pulmonary Aspergillosis (ABPA) patients across 23 centers in India
<bold>Introduction:</bold> We aimed to study the radiological presentations of ABPA patients across multiple centers in India. <bold>Methods:</bold> Pulmonologists from 23 sites registered with the Respiratory Research Network (RRN) centers collaborated in this observational study. ABPA patients visiting the clinics underwent chest X-ray and HRCT. Patients were categorized into 3 groups based on International Society for Human and Animal Mycology (ISHAM) 2021 criteria; Group 1: meeting ISHAM criteria, Group 2: meeting partial ISHAM criteria (HRCT positive or serological positive in any 2 parameters), and Group 3: physician diagnosed, not meeting ISHAM criteria. <bold>Results:</bold> Among 802 patients, 37.2% (299) were in group I, 50.2% (403) in group II, and 12.4% (100) in group III. Abnormal HRCT and Chest X-ray findings are reported in the Table. <table-wrap><object-id>erj;64/suppl_68/PA4019/T1</object-id><object-id>T1</object-id><object-id>t1</object-id><table><colgroup><col></col><col></col><col></col><col></col><col></col></colgroup><tbody><tr><td>Variable</td><td>Group I (N=299)</td><td>Group II (N=403)</td><td>Group III (N=100)</td><td>P-value</td></tr><tr><td></td><td>Percentage</td><td>Percentage</td><td>Percentage</td><td></td></tr><tr><td>HRCT Test</td><td></td><td></td><td></td><td></td></tr><tr><td>Normal</td><td>4.3%</td><td>16.1%</td><td>−</td><td></td></tr><tr><td>Bronchiectasis</td><td>81.1%</td><td>68.0%</td><td>−</td><td><0.001*</td></tr><tr><td>Presence of high attenuation mucus</td><td>24.9%</td><td>16.3%</td><td>−</td><td><0.001*</td></tr><tr><td>Centrilobular nodules</td><td>45.9%</td><td>32.7%</td><td>−</td><td><0.001*</td></tr><tr><td>Tree in bud appearance</td><td>30.2%</td><td>25.8%</td><td>−</td><td></td></tr><tr><td>Chest X-ray</td><td></td><td></td><td></td><td></td></tr><tr><td>Normal</td><td>15.7%</td><td>34.7%</td><td>72%</td><td></td></tr><tr><td>Parallel opacities</td><td>44.7%</td><td>25.6%</td><td>25%</td><td><0.001*</td></tr><tr><td>Ring Opacities</td><td>51.5%</td><td>32.7%</td><td>25%</td><td><0.001*</td></tr><tr><td>Finger-in-glove</td><td>23.0%</td><td>11.8%</td><td>0%</td><td><0.006*</td></tr><tr><td>Tramline opacities</td><td>40.0%</td><td>32.7%</td><td>25%</td><td></td></tr><tr><td>Fleeting opacities</td><td>28.9%</td><td>31.8%</td><td>16%</td><td></td></tr></tbody></table></table-wrap> *Significant p-values <0.05 <bold>Conclusion:</bold> ABPA patients fulfilling ISHAM criteria present with significant differences in HRCT and Chest X-ray finding as compared to those partially/not fulfilling the ISHAM criteria.
Authors
- Akashdeep Singh (ORCID: https://orcid.org/0000-0002-5513-8352)
- Praveen Valsalan
- Swapnil Gadhave (ORCID: https://orcid.org/0000-0002-1551-6259)
- Babaji Ghewade (ORCID: https://orcid.org/0000-0003-1553-7268)
- Aditya Jindal (ORCID: https://orcid.org/0000-0003-2471-1686)
- Kaushik Saha (ORCID: https://orcid.org/0000-0002-7151-1268)
- Deesha Ghorpade (ORCID: https://orcid.org/0000-0002-3315-620X)
- Raja Dhar (ORCID: https://orcid.org/0000-0002-6742-5674)
- Snehal Kulkarni (ORCID: https://orcid.org/0000-0001-8028-7934)
- Puneet Saxena (ORCID: https://orcid.org/0000-0003-1111-1008)
- Sapna Madas (ORCID: https://orcid.org/0000-0003-0733-4436)
- Surya Kant (ORCID: https://orcid.org/0000-0001-7520-5404)
- Ruchi Dua (ORCID: https://orcid.org/0000-0002-3208-673X)
- Vishwanath Gella (ORCID: https://orcid.org/0000-0003-0866-8999)
- Sushmeeta Chhowala
- Sundeep Salvi (ORCID: https://orcid.org/0000-0003-2292-9999)
- Venkata Nagarjuna Maturu (ORCID: https://orcid.org/0000-0002-3679-9497)
- Abhishek Sabale
- Syamal Sarkar
- R. Agarwal (ORCID: https://orcid.org/0009-0004-4434-8954)
- Rajendra Prasad (ORCID: https://orcid.org/0000-0001-9425-5423)
- Divyesh Kumar (ORCID: https://orcid.org/0000-0002-4277-9572)
- Rennis Davis
- Mohit Agrawal
- Amit Dave
- Jaideep Gogtay
- Abhinav Chaudhary
- Prashant N. Chhajed
- AR Paramez
- Pooja Bhalekar
- Sheetu Singh
- Sandesh Sawant
- Rakesh Godra
- Suresh Ananthraj
- Mangesh Chandolkar
Institutions
- University of Mumbai (IN)
- Aliah University (IN)
- Indira Gandhi Institute of Medical Sciences (IN)
- KPC Medical College and Hospital (IN)
- Government of Kerala (IN)
- CARE Hospitals (IN)
- King George's Medical University (IN)
- Dayanand Medical College & Hospital (IN)
- Jawaharlal Nehru Medical College (IN)
- M.V. Hospital and Research Centre (IN)
- Diabetes Care and Research Foundation (IN)
- Institute of Post Graduate Medical Education and Research (IN)
- Calcutta Research Group (IN)
- Sri Ramachandra Medical Centre (IN)
- Era's Lucknow Medical College and Hospital (IN)
- Education & Research Foundation (US)
- Birla Institute of Scientific Research (IN)
- Kerala Institute of Medical Sciences (IN)
- Yashoda Hospital (IN)
- Datta Meghe Institute of Higher Education and Research (IN)
- Bombay Hospital (IN)
- Asian Institute of Gastroenterology (IN)
- Aster Medcity (IN)
- Seema Dental College and Hospital (IN)
- Army Hospital Research and Referral (IN)
- Rajasthan Dental College and Hospital (IN)
- All India Institute of Medical Sciences Rishikesh (IN)
- Post Graduate Institute of Medical Education and Research (IN)
- Medical College and Hospital, Kolkata (IN)
- Central Institute of Psychiatry (IN)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.pa4019
- Primary Topic
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00