Comparison of different clinical control instruments to detect the change caused by physical exercise in people with moderate to severe asthma

Aerobic exercise training (AET) induces improvement in asthma clinical control in subjects with asthma; this change is assessed by different questionnaires of clinical control. <bold>Aim:</bold> To compare different questionnaires of clinical control in subjects with moderate to severe asthma that performed 2 models of AET. <bold>Methods:</bold> 55 subjects with asthma, optimized treatment, and clinically stable were randomized into the High-Intensity of Interval Training (HIIT) (n=28; 30x30sec; 80-140% of Wmax) or Constant-Load Exercise (CLE) (n=27; 60-80% of Wmax). <bold>Evaluations:</bold> Asthma clinical questionnaire (ACQ) versions 5, 6, and 7, and Asthma Clinical Test (ACT); Cardiopulmonary exercise testing, and lung function were assessed also. <bold>Results:</bold> Both AET models increased aerobic fitness compared with the baseline (delta 2.52±2.95 vs. 2.08±2.60, p<0.05), and ACQ in any version showed clinical improvement induced by AET. All versions of acq had a strong correlation. However, the instrument with the worst correlation and the lowest sensitivity and specificity to identify clinical improvement induced by AET was the ACT [Figure 1]. <bold>Conclusion:</bold> Any ACQ version could be used, but ACT appears to be less sensitive for detecting clinical improvement induced by AET. <fig><object-id>erj;64/suppl_68/PA4115/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>