Comparison of IOS and Spirometry as Lung Function Tests in a childhood acute lymphoblastic leukemia (ALL) survivors cohort and a helathy controls group

IOS and Spirometry are two different methods for evaluating lung function in children and adolescents. There is a particular focus on ALL survivors, as previous studies on these tests is lacking this patient group. This study aims to compare the two tests to identify the most valid and applicable method for assessing the function and the resistense, in both the large and small airways. It is expected that IOS will prove to be a more user-friendly test, and therefore provide more valid results compared to Spirometry. Additionally, IOS is anticipated to be more effective in assessing lung elasticity and resistance. Data were collected over a period of 4½ years (2019-2023) in Danish center for paediatric pulmonology and allergology, Aarhus University Hospital. Both groups were offered both IOS and Spirometry lung tests with reversibility. The tests were conducted by experienced respiratory nurses using validated and calibrated lung function devices. The study includes 226 participants (97 ALL survivors and 129 in the control group) aged 5-17.9 years. Until now in the study, the validity rate for IOS has been determined to be 56%, applicable to both groups combined. There are no figures available on the validity rate of spirometries. The study participants are matched by gender and age. The full analysed data/results will be presented at the ERS congress 2024.