Multifaceted analysis of serum biomarkers for autoimmune features in patients with idiopathic interstitial pneumonia: A post-hoc analysis of prospective multicenter cohort study

<bold>Background:</bold> Interstitial pneumonia with autoimmune features (IPAF) is attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, details of biomarkers and the treatment response in these patients have not been fully elucidated. <bold>Objective:</bold> To find useful serum biomarkers that reflect connective tissue disease (CTD)-related features and the classification of IPAF in patients with IIP. <bold>Methods:</bold> Newly diagnosed patients with IIP were prospectively enrolled in this multicenter cohort study. In post-hoc analysis, serum levels of C-X-C motif chemokine (CXCL) 10, CXCL1, CCL2, BAFF, leptin, and angiopoietin-2 were measured by enzyme-linked immunosorbent assay. <bold>Results:</bold> Two hundred twenty-two patients with IIP were enrolled between 2015 to 2020. The median observation period was 36 months. The proportion of IPAF was 11.7% (26 patients). In patients with high serum CXCL10, changes in both %FVC and %DLCO in one year significantly increased (p=0.014 and p=0.009, respectively), although other biomarkers did not. A higher proportion of patients with high CXCL10 were diagnosed as NSIP with OP overlap (p=0.003), had CTD-specific autoantibodies, and met IPAF classification criteria (p=0.003) than those with low CXCL10. When limited to patients with IPAF, patients with high CXCL10 showed higher increase in %FVC in one year (p=0.029). Finally, in multivariate analysis, high serum CXCL10 was a significant favorable prognostic factor (HR 0.368, p=0.005). <bold>Conclusions:</bold> High serum CXCL10 was associated with CTD-related features and the classification of IPAF in patients with IIP.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa4259
Primary Topic
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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article
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article

Multifaceted analysis of serum biomarkers for autoimmune features in patients with idiopathic interstitial pneumonia: A post-hoc analysis of prospective multicenter cohort study

Hiromitsu Sumikawa, Hironao Hozumi, Yuya Aono, Masahiro Shirai et al.
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
article

Multifaceted analysis of serum biomarkers for autoimmune features in patients with idiopathic interstitial pneumonia: A post-hoc analysis of prospective multicenter cohort study

Hiromitsu Sumikawa, Hironao Hozumi, Yuya Aono, Masahiro Shirai, Koshi Yokomura, Naoki Inui, Taisuke Akamatsu, Mikio Toyoshima, Hyogo Naoi, Masashi Kitani, Masato Karayama, Yusuke Kaida, Yuzo Suzuki, Noriyuki Enomoto, Yuko Tanaka, Kazuki Furuhashi, Kazuhiro Tabata, Yasutaka Mochizuka, Hideki Yasui, Kazutaka Mori, Noriyoshi Ogawa, Tomoyuki Fujisawa, Naoki Koshimizu, Yusuke Inoue, Masato Kono, Shusuke Yazawa, Shiro Imokawa, Hiroyuki Matsuda, Hiroaki Sugiura, Takafumi Suda, Masafumi Masuda, Yutaro Nakamura, Atsuki Fukada, Takehisa Sano
article en

Abstract

<bold>Background:</bold> Interstitial pneumonia with autoimmune features (IPAF) is attracting an attention in patients with idiopathic interstitial pneumonia (IIP). However, details of biomarkers and the treatment response in these patients have not been fully elucidated. <bold>Objective:</bold> To find useful serum biomarkers that reflect connective tissue disease (CTD)-related features and the classification of IPAF in patients with IIP. <bold>Methods:</bold> Newly diagnosed patients with IIP were prospectively enrolled in this multicenter cohort study. In post-hoc analysis, serum levels of C-X-C motif chemokine (CXCL) 10, CXCL1, CCL2, BAFF, leptin, and angiopoietin-2 were measured by enzyme-linked immunosorbent assay. <bold>Results:</bold> Two hundred twenty-two patients with IIP were enrolled between 2015 to 2020. The median observation period was 36 months. The proportion of IPAF was 11.7% (26 patients). In patients with high serum CXCL10, changes in both %FVC and %DLCO in one year significantly increased (p=0.014 and p=0.009, respectively), although other biomarkers did not. A higher proportion of patients with high CXCL10 were diagnosed as NSIP with OP overlap (p=0.003), had CTD-specific autoantibodies, and met IPAF classification criteria (p=0.003) than those with low CXCL10. When limited to patients with IPAF, patients with high CXCL10 showed higher increase in %FVC in one year (p=0.029). Finally, in multivariate analysis, high serum CXCL10 was a significant favorable prognostic factor (HR 0.368, p=0.005). <bold>Conclusions:</bold> High serum CXCL10 was associated with CTD-related features and the classification of IPAF in patients with IIP.

Kagoshima University (JP), Hamamatsu University School of Medicine (JP), Seirei Mikatabara General Hospital (JP), Shizuoka City Shimizu Hospital (JP), Hamamatsu University Hospital (JP), Iwata City Hospital (JP), Seirei Hamamatsu General Hospital (JP), Shizuoka City Hospital (JP), Shizuoka General Hospital (JP), Shizuoka Red Cross Hospital (JP), Fujieda Municipal General Hospital (JP), National Hospital Organization (JP), Tokyo National Hospital (JP), NHO Kinki Chuo Chest Medical Center (JP), National Defense Medical College (JP)
Good health and well-being
Openalex Percentile: Top 63%
Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
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