Real-world walking of people with COPD

Although there has been extensive research into physical activity limitation in people with COPD, little is known about the patterns of walking during daily life (i.e., real-world). We aimed to assess the levels and distribution of real-world walking (walking activity and gait parameters) in people with COPD compared with healthy adults (HA), and across disease severity; and to identify the domains of walking in COPD, using a single wearable device. In a cross-sectional study, 550 people with COPD (37% women, with a mean (SD) age of 68 (8) years, post-bronchodilator FEV1 54 (21) %) and 19 age-matched HA were recruited in ten cities across eight countries. Subjects were given a single wearable device to wear at their lower back for one week. Twenty-five walking activity and gait parameters (e.g., number of steps, number of walking bouts (WB)>30s, walking speed in WB>30s, cadence in WB>30s, walking speed and cadence variability) were derived from the device outputs. Most walking activity and gait parameters were reduced in COPD compared to HA, and according to COPD severity (Figure 1). Differences remained statistically significant after adjusting for age, sex, height and comorbidities in multivariable analyses. Factor analysis identified six distinct walking domains: Amount of walking, Patterns of walking, Pace, Rhythm, Pace variability and Rhythm variability. Real-world walking in people with COPD is a multi-dimensional behaviour that is impaired as the disease progresses. <fig><object-id>erj;64/suppl_68/PA4371/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa4371
Primary Topic
Chronic Obstructive Pulmonary Disease (COPD) Research
Type
article
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article

Real-world walking of people with COPD

Nicholas S Hopkinson, Jeffrey M. Hausdorff, Dimitrios Megaritis, Thierry Troosters et al.
Chronic Obstructive Pulmonary Disease (COPD) Research
article

Real-world walking of people with COPD

Nicholas S Hopkinson, Jeffrey M. Hausdorff, Dimitrios Megaritis, Thierry Troosters, Nikolaos Chynkiamis, Joren Buekers, Judith García‐Aymerich, Anja Frei, Laura Delgado‐Ortiz, Walter Maetzler, Silvia Del Din, Ioannis Vogiatzis, Clint Hansen, Lynn Rochester, Sarah Koch, Clemens Becker, Henrik Watz, Milo A. Puhan, Heleen Demeyer, Elena Gimeno‐Santos, Carl-Philipp Jansen, David Singleton, Guido Thoemmes, Brian Cauffield
article en

Abstract

Although there has been extensive research into physical activity limitation in people with COPD, little is known about the patterns of walking during daily life (i.e., real-world). We aimed to assess the levels and distribution of real-world walking (walking activity and gait parameters) in people with COPD compared with healthy adults (HA), and across disease severity; and to identify the domains of walking in COPD, using a single wearable device. In a cross-sectional study, 550 people with COPD (37% women, with a mean (SD) age of 68 (8) years, post-bronchodilator FEV1 54 (21) %) and 19 age-matched HA were recruited in ten cities across eight countries. Subjects were given a single wearable device to wear at their lower back for one week. Twenty-five walking activity and gait parameters (e.g., number of steps, number of walking bouts (WB)>30s, walking speed in WB>30s, cadence in WB>30s, walking speed and cadence variability) were derived from the device outputs. Most walking activity and gait parameters were reduced in COPD compared to HA, and according to COPD severity (Figure 1). Differences remained statistically significant after adjusting for age, sex, height and comorbidities in multivariable analyses. Factor analysis identified six distinct walking domains: Amount of walking, Patterns of walking, Pace, Rhythm, Pace variability and Rhythm variability. Real-world walking in people with COPD is a multi-dimensional behaviour that is impaired as the disease progresses. <fig><object-id>erj;64/suppl_68/PA4371/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>

University College Dublin (IE), Merck KGaA, Darmstadt (Germany) (DE), Universitat Pompeu Fabra (ES), Stavros Niarchos Foundation (GR), Tel Aviv Sourasky Medical Center (IL), Prevention Institute (US), Robert Bosch Stiftung (DE), Hochschule für Angewandte Wissenschaften Kiel (DE), Christian-Albrechts-Universität zu Kiel (DE), Northumbria University (GB), VIB-KU Leuven Center for Microbiology (BE), NIHR Newcastle Biomedical Research Centre (GB), LungenClinic Grosshansdorf (DE), The London College (GB), KU Leuven (BE)
Gender equality
Openalex Percentile: Top 63%
Chronic Obstructive Pulmonary Disease (COPD) Research
DOISourceOpenAlex
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