Impact of Indoor Air Pollution on Health Outcomes in Patients with Idiopathic Pulmonary Fibrosis

<bold>Introduction:</bold> While the effects of outdoor air pollution are well-known, those of indoor air pollution, particularly exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM 2.5), on patients with idiopathic pulmonary fibrosis (IPF) are unclear. Our study aimed to investigate the effects of indoor PM2.5 on the health outcomes in IPF patients. <bold>Methods:</bold> This multicenter prospective cohort study included 142 IPF patients from 12 institutions in South Korea. Quarterly assessments, including pulmonary function tests, quality of life questionnaires, and Krebs von den Lungen-6 (KL-6) level measurements, were performed over one year. Disease progression (DP) was defined as a relative decline of 10% in forced vital capacity (FVC) or 15% in diffusing capacity for carbon monoxide. Indoor PM2.5 levels were measured for five days at baseline and at 3, 6, and 9 months after enrollment using a MicroPEM device (RTI International, USA). <bold>Results:</bold> Of 142 participants, 127 with PM2.5 measurements were included (mean age: 69.4 years, male: 83.5%). The median value of annual average PM2.5 levels were 11.4 µg/m³ (interquartile range: 8.6-14.9 µg/m³). Baseline PM2.5 levels were correlated with KL-6 levels (r=0.216, p=0.016) and FVC (r = −0.159, p = 0.076). Cox regression analysis adjusting for clinical and socioeconomic factors showed that a 10 µg/m³ increase in annual average PM2.5 levels was associated with a 30.4% increase in DP (hazard ratio: 1.304, 95% confidence interval: 1.010—1.051). <bold>Conclusions:</bold> Indoor exposure to PM2.5 was correlated with higher KL-6 levels and increased the risk of DP in patients with IPF.

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Published
2024-09-14
DOI
https://doi.org/10.1183/13993003.congress-2024.pa4452
Primary Topic
Air Quality and Health Impacts
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article
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article

Impact of Indoor Air Pollution on Health Outcomes in Patients with Idiopathic Pulmonary Fibrosis

Hee‐Young Yoon, Ala Woo, Sun Mi Choi, Jae Hwa Cho et al.
Air Quality and Health Impacts
article

Impact of Indoor Air Pollution on Health Outcomes in Patients with Idiopathic Pulmonary Fibrosis

Hee‐Young Yoon, Ala Woo, Sun Mi Choi, Jae Hwa Cho, Song Yee Kim, Yong Suk Jo, Kyumin Kim, Hyung Koo Kang, Hoseob Kim, Jin Woo Song, Jimyung Park, Joo Hun Park, Ju Hyun Oh, Sungwoo Park, Sun‐Young Kim, Jong Min Lee, Yong Hyun Kim, Jong Sun Park, Eun-Joo Lee, Hongseok Yoo
article en

Abstract

<bold>Introduction:</bold> While the effects of outdoor air pollution are well-known, those of indoor air pollution, particularly exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM 2.5), on patients with idiopathic pulmonary fibrosis (IPF) are unclear. Our study aimed to investigate the effects of indoor PM2.5 on the health outcomes in IPF patients. <bold>Methods:</bold> This multicenter prospective cohort study included 142 IPF patients from 12 institutions in South Korea. Quarterly assessments, including pulmonary function tests, quality of life questionnaires, and Krebs von den Lungen-6 (KL-6) level measurements, were performed over one year. Disease progression (DP) was defined as a relative decline of 10% in forced vital capacity (FVC) or 15% in diffusing capacity for carbon monoxide. Indoor PM2.5 levels were measured for five days at baseline and at 3, 6, and 9 months after enrollment using a MicroPEM device (RTI International, USA). <bold>Results:</bold> Of 142 participants, 127 with PM2.5 measurements were included (mean age: 69.4 years, male: 83.5%). The median value of annual average PM2.5 levels were 11.4 µg/m³ (interquartile range: 8.6-14.9 µg/m³). Baseline PM2.5 levels were correlated with KL-6 levels (r=0.216, p=0.016) and FVC (r = −0.159, p = 0.076). Cox regression analysis adjusting for clinical and socioeconomic factors showed that a 10 µg/m³ increase in annual average PM2.5 levels was associated with a 30.4% increase in DP (hazard ratio: 1.304, 95% confidence interval: 1.010—1.051). <bold>Conclusions:</bold> Indoor exposure to PM2.5 was correlated with higher KL-6 levels and increased the risk of DP in patients with IPF.

Severance Hospital (KR), Soonchunhyang University Hospital Seoul (KR), Samsung Medical Center (KR), New Generation University College (ET), Seoul National University Bundang Hospital (KR), University of Ulsan (KR), National Cancer Center (US), St. Mary's Hospital (US), Hanmi Pharmaceutical (South Korea) (KR), Inje University Ilsan Paik Hospital (KR), St. Mary's Hospital (US), Inje University Sanggye Paik Hospital (KR), National Cancer Center (KR), The Catholic University of Korea Bucheon St. Mary's Hospital (KR), Myongji Hospital (KR), Gangnam Severance Hospital (KR), The Catholic University of Korea Seoul St. Mary's Hospital (KR), Korea University (JP), Ajou University (KR), Bucheon University (KR)
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Air Quality and Health Impacts
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