Prospective, non-interventional study to characterise use of triple therapy for COPD: TETRIS

<bold>Background:</bold> The TETRIS study aims to elucidate influences on treatment decisions surrounding triple therapy (TT) in patients with chronic obstructive pulmonary disease (COPD) over a 2-year follow-up (FU) period in a real-world setting in Germany. <bold>Methods:</bold> This prospective, non-interventional, multi-centre study included 1213 patients with COPD with/without asthma, already on TT for at least 2 wks but not >48 wks. Here we report interim analyses at 6- and 12-month FU visits (V2 and V3, respectively) in a subset of patients (n=840) stratified based on once vs. twice daily TT and treatment by general practitioner vs. pulmonologist. <bold>Results:</bold> Among the 840 patients, 765 and 742 completed V2 and V3, respectively. Majority of the patients were adherent to their initial TT. Overall, the absolute numbers of exacerbations (V2=36; V3=108) and hospitalisations (V2=45; V3=57) were low. There were differences between the observed strata regarding the mean number of exacerbations in V3 and the mean number and duration of hospitalisations due to exacerbations since last visit. Furthermore, changes in CAT sum score and EQ-5D-VAS score at V2 and V3 differed within the strata (table). <bold>Conclusions:</bold> Overall, TT is associated with improved symptoms and QoL and reduction in hospitalisations due to exacerbations at the 1-yr FU visit. Additionally, most patients have been adherent to their initial TT. Funding: GSK (214468) <fig><object-id>erj;64/suppl_68/PA4795/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>