Analysis of individuals presenting phenotypes of extreme high and low risk of developing tobbacco-induced lung cáncer.

<bold>INTRODUCTION:</bold> Lung cancer (LC) is asociated to tobacco exposure. Some heavy smokers develop lung cancer at a young age but others never develop LC, even at an advanced age. This suggests a significant variability in the individual susceptibility to the carcinogenic effects of tobacco. <bold>METHODS:</bold> We analyzed differences between groups of individuals with high tobacco exposure (index packages year (IPA) > 15), presenting extreme phenotypes. Hevy smokers who developed LC at early age (≤ 50 years old, n= 57) and heavy smokers who did not develop LC at advanced age (>70 years old, n= 83). We studied presence, severity and extension of emphysema, presence of a GOLD defined obstructive pattern (post bronchodilator FEV1/FVC<0.70), body mass index (IMC) [kg/m^2], family background of LC and current smoking habit. <bold>RESULTS:</bold> Illustrated in figure 1. Presence of LC family background, lower BMI, and emphysema were significantly more frecuent in individuals with LC diagnosis at early age. Time of smoking cesation was significantly longer in individuals who did not develop LC at advanced age. <bold>CONCLUSIONS:</bold> In heavy smokers the main predictors of LC diagnosis at early age were LC family background, lower BMI and emphysema, whereas longer time of smoking cesation was asociated to absence of development of LC at advanced age. <fig><object-id>erj;64/suppl_68/PA4448/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>