APPaRENT 1 & 2 surveys: post-hoc analysis to assess predictors of asthma treatment adherence

<bold>Introduction:</bold> Good adherence to maintenance medication is key to improve asthma outcomes. <bold>Aims:</bold> Identify patient characteristics associated with adherence and ways to improve current asthma care through survey post-hoc analysis. <bold>Methods:</bold> APPaRENT 1&2 were online surveys across 9 countries in 2020–2021 assessing patient and physician perspectives on asthma management. Patients were aged ≥18 years with self-reported history of physician-diagnosed asthma. Good adherence was defined as inhaled corticosteroid (ICS)-based treatment ≥once a day. <bold>Results:</bold> Patients (N=2866) and physicians (N=1883) reported good adherence rates of 60.5% vs 70.8%, respectively, and differing perspectives on treatment and goal setting. Older age, more severe disease, and more frequent reliever use were associated with higher odds of good adherence (Figure). Likelihood of good regimen adherence was higher with ICS proactive regular dosing vs maintenance and reliever therapy (MART). Use of an additional reliever with MART was associated with household smoking, severe or poorly controlled asthma, and living in China or the Philippines. <bold>Conclusions:</bold> Age, asthma severity and reliever use should be considered when personalising asthma care to optimise adherence and clinical outcomes. More physician-patient collaboration to agree on goals, encourage appropriate medication use and regular follow-ups would advance care. <bold>Funding:</bold> GSK (Study IDs: 212911&214325). <fig><object-id>erj;64/suppl_68/PA4491/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig>