Role of ROSE during EBUS-TBNA in improving the microbiological yield in suspected mediastinal TB lymphadenopathy, a UK multi-centre cohort study.
<bold>Background:</bold> Rapid On-Site Evaluation (ROSE) of lymph node specimens during EBUS-TBNA seeks to ensure the adequacy of sampling and/or find a preliminary pathology. The integration of ROSE can help in a rapid diagnosis of granulomatous disease and may enhance the microbiological yield by allowing better targeting of nodes and optimisation of sample destination. <bold>Objective:</bold> To evaluate the role of ROSE in a UK adult population for suspected TB lymphadenopathy in increasing the microbiological yield for AFB culture. <bold>Methods:</bold> Patients who underwent EBUS-TBNA for suspected TB lymphadenopathy with cytology, AFB culture, TB PCR and +/- ROSE were included. Retrospective data were collected between 2018–2019 in one centre and prospective data in 2021–2022 across 10 UK centres. Electronic health records were used for demographical and clinical details. <bold>Results:</bold> 551 EBUS were analysed. The turnaround time (TAT) for culture confirmation and yield was higher in ROSE group. <fig><object-id>erj;64/suppl_68/PA5052/F1</object-id><object-id>F1</object-id><object-id>F1</object-id><graphic></graphic></fig> <bold>Conclusion:</bold> The use of ROSE during EBUS-TBNA appears to be associated with a higher microbiological yield and shortened TAT for TB. <fig><object-id>erj;64/suppl_68/PA5052/F2</object-id><object-id>F2</object-id><object-id>F2</object-id><graphic></graphic></fig>
Authors
- Helen J. Burgess (ORCID: https://orcid.org/0000-0003-3816-8194)
- Onn Min Kon (ORCID: https://orcid.org/0000-0003-2647-4688)
- Giovanni Satta (ORCID: https://orcid.org/0000-0002-0120-7885)
- Mirae Park (ORCID: https://orcid.org/0000-0002-7015-5943)
- Ashley Whittington
- T Gorsuch
- Michael R. Loebinger (ORCID: https://orcid.org/0000-0002-5965-9913)
- L. M. Casado Moragon Luis Martín
- A Dunleavy
- Meg Coleman (ORCID: https://orcid.org/0000-0002-1298-5156)
- Kavina Manalan
- Marc Lipman (ORCID: https://orcid.org/0000-0001-7501-4448)
- Arnab Datta (ORCID: https://orcid.org/0000-0002-9220-7812)
- O. Hatem
- Heinke Kunst (ORCID: https://orcid.org/0000-0002-0380-1116)
- Pranabashis Haldar (ORCID: https://orcid.org/0000-0002-1572-5421)
- B Tomas-Cordero
- Lianne Castle
- Mohammed Munavvar (ORCID: https://orcid.org/0000-0002-9493-3965)
- Shadab Khan (ORCID: https://orcid.org/0000-0001-6767-2803)
- Ronan Breen
- Jadranka Vidak
- Geeja Srilal
- Kalia Parul
- Joan Nanna
Institutions
- Lancashire Teaching Hospitals NHS Foundation Trust (GB)
- University College London Hospitals NHS Foundation Trust (GB)
- Imperial College Healthcare NHS Trust (GB)
- Royal Free London NHS Foundation Trust (GB)
- Guy's and St Thomas' NHS Foundation Trust (GB)
- Barts Health NHS Trust (GB)
- Chelsea and Westminster Hospital NHS Foundation Trust (GB)
- London North West Healthcare NHS Trust (GB)
- St George’s University Hospitals NHS Foundation Trust (GB)
- West Middlesex University Hospital (GB)
- University Hospitals of Leicester NHS Trust (GB)
- Manchester University NHS Foundation Trust (GB)
Publication Details
- Published
- 2024-09-14
- DOI
- https://doi.org/10.1183/13993003.congress-2024.pa5052
- Primary Topic
- Mycobacterium research and diagnosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00